論文 - 詳細
| RRC ID | 43798 |
|---|---|
| 著者 | Itoh T, Ito Y, Ohtsuki Y, Ando M, Tsukamasa Y, Yamada N, Naoe T, Akao Y. |
| タイトル | Microvesicles released from hormone-refractory prostate cancer cells facilitate mouse pre-osteoblast differentiation. |
| ジャーナル | J Mol Histol |
| Abstract |
Bone metastasis is often occurs in patients with prostate cancer. There is a vicious cycle for bone metastases involving prostate cancer cells, osteoblasts, and osteoclasts. Acting among those cells during the process of metastasis are several molecules such as bone morphogenetic proteins, platelet-derived growth factor, endothelin-1, matrix metalloproteases, vascular endothelial growth factor, transforming growth factor-β, and insulin-like growth factors. Cell-derived microvesicles are endogenous carriers transporting proteins, mRNAs and miRNAs between cells, which is a candidate for participation in the bone metastasis of these cells. Here, we demonstrated that prostate cancer cells in vitro released microvesicles into the culture medium (PCa-MVs), which was shown by electron microscopic study and nanoparticle tracking analysis. In this study, we found for the first time that these PCa-MVs enhanced osteoblast differentiation mainly through the delivery of PCa cell-derived v-ets erythroblastosis virus E26 oncogene homolog 1, which is an osteoblast differentiation related-transcriptional factor. |
| 巻・号 | 43(5) |
| ページ | 509-15 |
| 公開日 | 2012-10-1 |
| DOI | 10.1007/s10735-012-9415-1 |
| PMID | 22526510 |
| PMC | PMC3460166 |
| MeSH | Animals Bone Neoplasms / metabolism Bone Neoplasms / secondary Cell Differentiation* Cell Line, Tumor Culture Media, Conditioned* Gene Expression Regulation, Neoplastic Humans Male Mice Nanoparticles / ultrastructure Neoplasm Metastasis Neoplasms, Hormone-Dependent* / metabolism Neoplasms, Hormone-Dependent* / pathology Osteoblasts* / cytology Osteoblasts* / pathology Osteoclasts / cytology Osteoclasts / pathology Prostatic Neoplasms* / metabolism Prostatic Neoplasms* / pathology RNA, Messenger / metabolism Signal Transduction |
| IF | 2.531 |
| 引用数 | 23 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |