論文 - 詳細
| RRC ID | 43799 |
|---|---|
| 著者 | Yang C, Wang Y, Chen X. |
| タイトル | Mineralization regulation and biological influence of bioactive glass-collagen-phosphatidylserine composite scaffolds. |
| ジャーナル | Sci China Life Sci |
| Abstract |
Biomimetic scaffolds are appealing products for the repair of bone defects using tissue engineering strategies. In the present study, novel biomimetic composite scaffolds, with similar properties to natural bone, were prepared, blended and cross-linked with bioactive glass, type I collagen and phosphatidylserine. When exposed to cell culture solution in the absence of a cellular source, the composite scaffolds form crystals with octahedral structure. These crystals are similar to the products derived from MC3T3-E1 cell mineralization within the composite scaffolds, with respect to both composition and morphology. Furthermore, crystals with octahedral structure were observed to develop into plate-like hydroxyapatite. The bio-mineralization behavior of the composite scaffolds is likely influenced by inorganic components. Finally, a rabbit tibia defect model shows that the highly bioactive properties of the investigated composites result in excellent bone repair. |
| 巻・号 | 55(3) |
| ページ | 236-40 |
| 公開日 | 2012-3-1 |
| DOI | 10.1007/s11427-012-4291-1 |
| PMID | 22527520 |
| MeSH | 3T3 Cells Animals Biocompatible Materials / chemistry Bone Regeneration Bone Substitutes / chemistry Bone and Bones / pathology Collagen Type I / metabolism Crystallization Glass / chemistry* Mice Microscopy, Electron, Scanning / methods Phosphatidylserines / chemistry Rabbits Tibia / pathology Time Factors Tissue Engineering / methods Tissue Scaffolds |
| IF | 4.611 |
| 引用数 | 8 |
| WOS 分野 | BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |