| RRC ID |
4380
|
| 著者 |
Masuyama T, Miyajima K, Ohshima H, Osawa M, Yokoi N, Oikawa T, Taniguchi K.
|
| タイトル |
A novel autosomal-recessive mutation, whitish chalk-like teeth, resembling amelogenesis imperfecta, maps to rat chromosome 14 corresponding to human 4q21.
|
| ジャーナル |
Eur J Oral Sci
|
| Abstract |
A rat mutant, whitish chalk-like teeth (wct), with white, chalk-like abnormal incisors, was discovered and morphologically and genetically characterized. The mutant rats showed tooth enamel defects that were similar to those of human amelogenesis imperfecta. The wct mutation was found to disturb the morphological transition of ameloblasts from secretory to maturation stages and to induce cyst formation. This mutation also disturbs the transfer of iron into the enamel, resulting in the whitish chalk-like incisors. A genetic linkage study indicated that the wct locus maps to a specific interval of rat chromosome 14 between D14Got13 and D14Wox2. Interestingly, the human chromosomal region orthologous to wct, a 5.5-Mb interval in human chromosome 4q21, is a critical region for the locus of human amelogenesis imperfecta AIH2. These results strongly suggest that this wct mutant is a useful model for the identification of genes responsible for amelogenesis imperfecta and molecular mechanisms of tooth development.
|
| 巻・号 |
113(6)
|
| ページ |
451-6
|
| 公開日 |
2005-12-1
|
| DOI |
10.1111/j.1600-0722.2005.00254.x
|
| PII |
EOS254
|
| PMID |
16324133
|
| MeSH |
Ameloblasts / cytology*
Amelogenesis Imperfecta / genetics*
Animals
Cell Differentiation
Chromosome Disorders / genetics*
Chromosome Mapping*
Chromosomes, Human, Pair 4
Disease Models, Animal
Female
Genes, Recessive / genetics*
Genetic Linkage
Humans
Male
Mice
Rats
Rats, Inbred F344
Rats, Mutant Strains / genetics*
Rats, Sprague-Dawley
|
| IF |
2.22
|
| 引用数 |
5
|
|
WOS 分野
|
DENTISTRY, ORAL SURGERY & MEDICINE
|
| リソース情報 |
| ラット |
WT/Jtt(strainID=476) |
