| RRC ID |
43812
|
| 著者 |
Furuya R, Hu H, Zhang Z, Shigemori H.
|
| タイトル |
Suffruyabiosides A and B, two new monoterpene diglycosides from moutan cortex.
|
| ジャーナル |
Molecules
|
| Abstract |
Two new monoterpene diglycosides, suffruyabiosides A and B, and seven known compounds 3-9 were isolated from Moutan Cortex (root cortex of Paeonia suffruticosa Andrews). The structures were elucidated on the basis of 2D NMR spectral data. Suffruyabiosides A and B are rare monoterpene diglycosides, including a cellobiose in the molecules. Salicylpaeoniflorin (4) had a antiproliferation effect similar to paeoniflorin (3) on human lung adenocarcinoma epitherial A549 cells. Galloylpaeoniflorin (8) and salicylpaeoniflorin (4) revealed a more pronounced radical scavenging effect than a-tocopherol (positive control). An increase in the number of phenolic hydroxyl groups produced a more effective radical scavenging effect [8 > mudanpioside E (6) > oxypaeoniflorin (5)]. Comparison of the effects of 4 and 5 showed that o-substitution with a phenolic hydroxyl group was more effective than p-substitution. The results suggest that salicylpaeoniflorin (4) may be useful as a cytotoxic and a radical scavenging agent.
|
| 巻・号 |
17(5)
|
| ページ |
4915-23
|
| 公開日 |
2012-4-30
|
| DOI |
10.3390/molecules17054915
|
| PII |
molecules17054915
|
| PMID |
22547314
|
| PMC |
PMC6268304
|
| MeSH |
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Drugs, Chinese Herbal / chemistry*
Ethanol / chemistry
Free Radical Scavengers / chemistry*
Free Radical Scavengers / isolation & purification
Free Radical Scavengers / pharmacology
Glucosides / chemistry*
Glucosides / isolation & purification
Glucosides / pharmacology
Glycosides / chemistry*
Glycosides / isolation & purification
Glycosides / pharmacology
Humans
Magnetic Resonance Spectroscopy
Monoterpenes / chemistry*
Monoterpenes / isolation & purification
Monoterpenes / pharmacology
Paeonia / chemistry*
Plant Extracts / chemistry*
Plant Roots / chemistry
alpha-Tocopherol / pharmacology
|
| IF |
3.267
|
| 引用数 |
10
|
|
WOS 分野
|
CHEMISTRY, ORGANIC
|
| リソース情報 |
| ヒト・動物細胞 |
A549(RCB0098) |
