| RRC ID |
43820
|
| 著者 |
Brahatheeswaran D, Mathew A, Aswathy RG, Nagaoka Y, Venugopal K, Yoshida Y, Maekawa T, Sakthikumar D.
|
| タイトル |
Hybrid fluorescent curcumin loaded zein electrospun nanofibrous scaffold for biomedical applications.
|
| ジャーナル |
Biomed Mater
|
| Abstract |
Nanomedicine utilizes engineered nanodevices and nanostructures for monitoring, repair, construction and control of human biological systems at the molecular level. In this study, we investigated the feasibility and potential of zein nanofiber as a delivery vehicle for curcumin in biomedical applications. By optimizing the electrospinning parameters, ultrafine zein fluorescence nanofibers containing curcumin were developed with interconnected fibrous networks. We found that these nanofibers show an increase in fluorescence due to the incorporation of curcumin. The morphology and material properties of the resulting multifunctional nanofiber including the surface area were examined by a field emission-scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and confocal microscopy. The surface area and pore size were characterized by N(2) adsorption-desorption isotherm. SEM and fluorescence images showed that the uniform fibers with smooth surface had an average diameter of about 310 nm. An in vitro degradation study showed significant morphological changes. The in vitro evaluations suggested that the curcumin incorporated zein nanofibers showed sustained release of curcumin and maintained its free radical scavenging ability. It provides an attractive structure for the attachment and growth of fibroblast as cell culture surfaces. The results demonstrate that the curcumin loaded zein nanofiber could be a good candidate for soft tissue engineering scaffolds and has the potential for further applications in drug delivery system.
|
| 巻・号 |
7(4)
|
| ページ |
045001
|
| 公開日 |
2012-8-1
|
| DOI |
10.1088/1748-6041/7/4/045001
|
| PMID |
22556150
|
| MeSH |
Antioxidants / chemistry
Biocompatible Materials / chemistry
Cell Culture Techniques
Curcumin / administration & dosage*
Drug Delivery Systems*
Fibroblasts / cytology
Free Radical Scavengers
Free Radicals
Humans
Microscopy, Confocal / methods
Microscopy, Electron, Scanning / methods
Nanofibers / chemistry*
Nanomedicine / methods
Spectroscopy, Fourier Transform Infrared / methods
Thermogravimetry / methods
Tissue Engineering
Zein / chemistry*
|
| IF |
3.174
|
| 引用数 |
93
|
|
WOS 分野
|
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
| リソース情報 |
| ヒト・動物細胞 |
L929 |
