Reference - Detail
| RRC ID | 43932 |
|---|---|
| Author | Kawaii S, Endo K, Tokiwano T, Yoshizawa Y. |
| Title | Relationship between structure and antiproliferative activity of 1-azaflavanones. |
| Journal | Anticancer Res |
| Abstract |
The synthesis of 19 derivatives of 2-phenyl-3,4-dihydroquinolin-4(1H)-one, as aza analogs of flavanones, was carried out and these compounds were further screened for their antiproliferative activity toward HL60 promyelocytic leukemia cells. In comparison with flavanone the replacement of C-ring ether oxygen atom with a nitrogen atom potentiated activity by more than 100-fold. It was suggested that the aromaticity of the B-ring contributes greatly to the activity of 1-azaflavanones. |
| Volume | 32(7) |
| Pages | 2819-25 |
| Published | 2012-7-1 |
| PII | 32/7/2819 |
| PMID | 22753743 |
| MeSH | Antineoplastic Agents / chemical synthesis Antineoplastic Agents / chemistry* Antineoplastic Agents / pharmacology* Aza Compounds / chemical synthesis Aza Compounds / chemistry* Aza Compounds / pharmacology* Cell Growth Processes / drug effects Drug Screening Assays, Antitumor Flavanones / chemical synthesis Flavanones / chemistry* Flavanones / pharmacology* HL-60 Cells Humans Structure-Activity Relationship |
| IF | 1.994 |
| Times Cited | 9 |
| WOS Category | ONCOLOGY |
| Resource | |
| Human and Animal Cells | |