論文 - 詳細
| RRC ID | 43947 |
|---|---|
| 著者 | Kikuchi T, Zhang J, Huang Y, Watanabe K, Ishii K, Yamamoto A, Fukatsu M, Tanaka R, Akihisa T. |
| タイトル | Glycosidic inhibitors of melanogenesis from leaves of Momordica charantia. |
| ジャーナル | Chem Biodivers |
| Abstract |
Eight glycosidic compounds, 1-8, including two new compounds, (4ξ)-α-terpineol 8-O-[α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside] (5) and myrtenol 10-O-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside] (7), were isolated from the BuOH-soluble fraction of a MeOH extract of Momordica charantia leaves. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analyses and comparison with literature. Upon evaluation of compounds 1-8 on the melanogenesis in B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), these compounds were found to exhibit inhibitory activities with 7.1-27.0% and 23.6-46.4% reduction of melanin content at 30 μM and 100 μM, respectively, with no or almost no toxicity to the cells (80.0-103.5% of cell viability at 100 μM). Western blot analysis showed that compound 7 reduced the protein levels of MITF, tyrosinase, TRP-1, and TRP-2 mostly in a concentration-dependent manner, suggesting that this compound inhibits melanogenesis on the α-MSH-stimulated B16 melanoma cells by, at least in part, inhibiting the expression of MITF, followed by decreasing the expression of tyrosinase, TRP-1, and TRP-2. |
| 巻・号 | 9(7) |
| ページ | 1221-30 |
| 公開日 | 2012-7-1 |
| DOI | 10.1002/cbdv.201100350 |
| PMID | 22782871 |
| MeSH | Animals Antineoplastic Agents / chemistry Antineoplastic Agents / pharmacology Cell Line, Tumor Cell Survival / drug effects Glycosides / chemistry Glycosides / pharmacology* Magnetic Resonance Spectroscopy Melanins / antagonists & inhibitors* Melanins / metabolism Mice Momordica charantia / chemistry* Plant Leaves / chemistry* |
| IF | 2.039 |
| 引用数 | 12 |
| WOS 分野 | CHEMISTRY, MULTIDISCIPLINARY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |