| RRC ID |
43970
|
| Author |
Doi K, Fujimoto T, Okamura T, Ogawa M, Tanaka Y, Mototani Y, Goto M, Ota T, Matsuzaki H, Kuroki M, Tsunoda T, Sasazuki T, Shirasawa S.
|
| Title |
ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
ZFAT, originally identified as a candidate susceptibility gene for autoimmune thyroid disease, has been reported to be involved in apoptosis, development and primitive hematopoiesis. Zfat is highly expressed in T- and B-cells in the lymphoid tissues, however, its physiological function in the immune system remains totally unknown. Here, we generated the T cell-specific Zfat-deficient mice and demonstrated that Zfat-deficiency leads to a remarkable reduction in the number of the peripheral T cells. Intriguingly, a reduced expression of IL-7Rα and the impaired responsiveness to IL-7 for the survival were observed in the Zfat-deficient T cells. Furthermore, a severe defect in proliferation and increased apoptosis in the Zfat-deficient T cells following T cell receptor (TCR) stimulation was observed with a reduced IL-2Rα expression as well as a reduced IL-2 production. Thus, our findings reveal that Zfat is a critical regulator in peripheral T cell homeostasis and its TCR-mediated response.
|
| Volume |
425(1)
|
| Pages |
107-12
|
| Published |
2012-8-17
|
| DOI |
10.1016/j.bbrc.2012.07.065
|
| PII |
S0006-291X(12)01361-7
|
| PMID |
22828507
|
| MeSH |
Animals
Apoptosis / immunology
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes / immunology*
Cell Proliferation
Homeostasis / immunology*
Interleukin-7 / pharmacology
Mice
Mice, Mutant Strains
Receptors, Antigen, T-Cell / immunology*
Receptors, Interleukin-7 / biosynthesis
Transcription Factors / genetics
Transcription Factors / physiology*
|
| IF |
2.985
|
| Times Cited |
12
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
|
