RRC ID 4398
著者 Ochiai E, Kamei K, Watanabe A, Nagayoshi M, Tada Y, Nagaoka T, Sato K, Sato A, Shibuya K.
タイトル Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice.
ジャーナル Int J Exp Pathol
Abstract Inhalation of Stachybotrys chartarum, a ubiquitous fungus in our living environment, has been suspected as a cause of acute idiopathic pulmonary haemorrhage in infants, but its relation to human diseases is not yet known. The aim of present study was to investigate the effect of repeated intratracheal injection of the fungus into mice, paying special attention to the pulmonary vascular system. Spores of S. chartarum were injected into the trachea of mice from 6 to 18 times over 4-12 weeks, and the lungs were examined by histopathology, morphometrics and haemodynamics. When 1 x 10(4) spores/mouse were injected, histopathological examination showed the development of pulmonary arterial hypertension (PAH). Symmetrical thickening of the intima and media of the pulmonary arterial walls was seen after six injections over 4 weeks. Right ventricular hypertrophy was also evident after 12 injections. PAH was confirmed by the elevation of right ventricular systolic pressure (20.1 +/- 5.7 mmHg in the injected group vs. 12.0 +/- 2.4 mmHg in the control group, P < 0.01). This study showed that the inhalation of S. chartarum caused PAH in mice, suggesting a potential of S. chartarum as a cause of human health problem such as PAH.
巻・号 89(3)
ページ 201-8
公開日 2008-6-1
DOI 10.1111/j.1365-2613.2008.00585.x
PII IEP585
PMID 18460072
PMC PMC2525769
MeSH Animals Arterial Occlusive Diseases / complications Arterial Occlusive Diseases / microbiology Arterial Occlusive Diseases / pathology Arterial Occlusive Diseases / physiopathology Hemodynamics Hypertension, Pulmonary / microbiology* Hypertension, Pulmonary / pathology Hypertension, Pulmonary / physiopathology Inhalation Exposure Lung Diseases, Fungal / complications* Lung Diseases, Fungal / pathology Lung Diseases, Fungal / physiopathology Male Mice Mice, Inbred Strains Pulmonary Artery / pathology Spores, Fungal / pathogenicity Stachybotrys / pathogenicity* Virulence
IF 1.672
引用数 14
WOS 分野 PATHOLOGY
リソース情報
病原微生物 IFM 53637