| RRC ID |
43996
|
| Author |
Matsuo K, Nakagawa H, Adachi Y, Kameda E, Aizawa K, Tsumoto H, Suzuki T, Miyata N.
|
| Title |
Photoinduced upregulation of calcitonin gene-related peptide in A549 cells through HNO release from a hydrophilic photocontrollable HNO donor.
|
| Journal |
Chem Pharm Bull (Tokyo)
|
| Abstract |
Nitroxyl (HNO), a one-electron-reduced form of nitric oxide, has various biological activities, including a cardioprotective effect. Here, we first synthesized another, more hydrophilic photocontrollable HNO donor (3), which can release HNO in a spatially and temporally controlled manner, and then examined the properties of our series of compounds as practical HNO donors in a cellular system under photocontrol. We selected compound 2 as the preferred donor, and used it to show that calcitonin gene-related peptide (CGRP) can be upregulated in A549 cells via photocontrolled HNO release. This result demonstrates the suitability of this photocontrollable HNO donor for biological investigations.
|
| Volume |
60(8)
|
| Pages |
1055-62
|
| Published |
2012-1-1
|
| DOI |
10.1248/cpb.c12-00348
|
| PII |
DN/JST.JSTAGE/cpb/c12-00348
|
| PMID |
22863710
|
| MeSH |
Calcitonin Gene-Related Peptide / metabolism*
Cell Line
Chromatography, Gas
Humans
Magnetic Resonance Spectroscopy
Nitrogen Oxides / pharmacology*
Photochemical Processes*
Spectrometry, Mass, Fast Atom Bombardment
Up-Regulation*
|
| IF |
1.416
|
| Times Cited |
6
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
CHEMISTRY, MULTIDISCIPLINARY
CHEMISTRY, MEDICINAL
|
| Resource |
| Human and Animal Cells |
A549(RCB0098) |
