Reference - Detail
| RRC ID | 43996 |
|---|---|
| Author | Matsuo K, Nakagawa H, Adachi Y, Kameda E, Aizawa K, Tsumoto H, Suzuki T, Miyata N. |
| Title | Photoinduced upregulation of calcitonin gene-related peptide in A549 cells through HNO release from a hydrophilic photocontrollable HNO donor. |
| Journal | Chem Pharm Bull (Tokyo) |
| Abstract |
Nitroxyl (HNO), a one-electron-reduced form of nitric oxide, has various biological activities, including a cardioprotective effect. Here, we first synthesized another, more hydrophilic photocontrollable HNO donor (3), which can release HNO in a spatially and temporally controlled manner, and then examined the properties of our series of compounds as practical HNO donors in a cellular system under photocontrol. We selected compound 2 as the preferred donor, and used it to show that calcitonin gene-related peptide (CGRP) can be upregulated in A549 cells via photocontrolled HNO release. This result demonstrates the suitability of this photocontrollable HNO donor for biological investigations. |
| Volume | 60(8) |
| Pages | 1055-62 |
| Published | 2012-1-1 |
| DOI | 10.1248/cpb.c12-00348 |
| PII | DN/JST.JSTAGE/cpb/c12-00348 |
| PMID | 22863710 |
| MeSH | Calcitonin Gene-Related Peptide / metabolism* Cell Line Chromatography, Gas Humans Magnetic Resonance Spectroscopy Nitrogen Oxides / pharmacology* Photochemical Processes* Spectrometry, Mass, Fast Atom Bombardment Up-Regulation* |
| IF | 1.416 |
| Times Cited | 6 |
| WOS Category | PHARMACOLOGY & PHARMACY CHEMISTRY, MULTIDISCIPLINARY CHEMISTRY, MEDICINAL |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | A549(RCB0098) |