論文 - 詳細
| RRC ID | 44008 |
|---|---|
| 著者 | Akihisa T, Watanabe K, Yamamoto A, Zhang J, Matsumoto M, Fukatsu M. |
| タイトル | Melanogenesis inhibitory activity of monoterpene glycosides from Gardeniae Fructus. |
| ジャーナル | Chem Biodivers |
| Abstract |
A new iridoid glycoside, 10-O-(4"-O-methylsuccinoyl)geniposide (7), and two new pyronane glycosides, jasminosides Q and R (13 and 14, resp.), along with nine known iridoid glycosides, 1-6 and 8-10, and two known pyronane glycosides, 11 and 12, were isolated from a MeOH extract of Gardeniae Fructus, the dried ripe fruit of Gardenia jasminoides (Rubiaceae). The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses and comparison with literature. Upon evaluation of compounds 1-14 on the melanogenesis in B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), three compounds, i.e., 6-O-p-coumaroylgeniposide (3), 7, and 6'-O-sinapoyljasminoside (12), exhibited inhibitory effects with 21.6-41.0 and 37.5-47.7% reduction of melanin content at 30 and 50 μM, respectively, with almost no toxicity to the cells (83.7-106.1% of cell viability at 50 μM). |
| 巻・号 | 9(8) |
| ページ | 1490-9 |
| 公開日 | 2012-8-1 |
| DOI | 10.1002/cbdv.201200030 |
| PMID | 22899609 |
| MeSH | Animals Cell Line, Tumor Cell Survival / drug effects Fruit / chemistry Gardenia / chemistry* Glycosides / chemistry* Glycosides / isolation & purification Glycosides / pharmacology* Melanins / antagonists & inhibitors* Melanins / metabolism Melanoma, Experimental / metabolism Monoterpenes / chemistry* Monoterpenes / isolation & purification Monoterpenes / pharmacology* |
| IF | 2.039 |
| 引用数 | 10 |
| WOS 分野 | CHEMISTRY, MULTIDISCIPLINARY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |