Reference - Detail
| RRC ID | 44009 |
|---|---|
| Author | Kikuchi T, Watanabe K, Tochigi Y, Yamamoto A, Fukatsu M, Ezaki Y, Tanaka R, Akihisa T. |
| Title | Melanogenesis inhibitory activity of sesquiterpenes from Canarium ovatum resin in mouse B16 melanoma cells. |
| Journal | Chem Biodivers |
| Abstract |
Four known sesquiterpene alcohols, i.e., 1-4, ten triterpene alcohols, i.e., 5-14, and four triterpene acids, i.e., 15-18, were isolated from the MeOH extract of Canarium ovatum resin (elemi resin). Upon evaluation of the previously described compounds 1-18 on the melanogenesis in B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), three sesquiterpene alcohols, i.e., cryptomeridiol (1), 4-epicryptomeridiol (2), and cadin-1(14)-ene-7α,11-diol (4), exhibited inhibitory effects with 27.4-34.1 and 39.0-56.9% reduction of melanin content at 50 and 100 μM, respectively, with no or very low toxicity to the cells (80.9-103.9% of cell viability at 100 μM). Western-blot analysis revealed that compounds 1 and 2 reduced the protein levels of MITF (=microphtalmia-associated transcription factor), tyrosinase, and TRP-2 (=tyrosine-related protein 2), mostly in a concentration-dependent manner, suggesting that these compounds exhibit melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells by, at least in part, inhibiting the expression of MITF, followed by decreasing the expression of tyrosinase and TRP-2. Three sesquiterpene alcohols, i.e., 1, 2, and 4, are, therefore, considered to be valuable as potential skin-whitening agents. |
| Volume | 9(8) |
| Pages | 1500-7 |
| Published | 2012-8-1 |
| DOI | 10.1002/cbdv.201200111 |
| PMID | 22899610 |
| MeSH | Animals Burseraceae / chemistry* Cell Line, Tumor Cell Survival / drug effects Melanins / antagonists & inhibitors* Melanins / metabolism Melanoma, Experimental / metabolism* Mice Microphthalmia-Associated Transcription Factor / antagonists & inhibitors Microphthalmia-Associated Transcription Factor / metabolism Monophenol Monooxygenase / antagonists & inhibitors Monophenol Monooxygenase / metabolism Resins, Plant / chemistry* Resins, Plant / isolation & purification Resins, Plant / pharmacology* Sesquiterpenes / chemistry* Sesquiterpenes / isolation & purification Sesquiterpenes / pharmacology* alpha-MSH / antagonists & inhibitors alpha-MSH / metabolism |
| IF | 2.039 |
| Times Cited | 10 |
| WOS Category | CHEMISTRY, MULTIDISCIPLINARY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| Human and Animal Cells | B16 melanoma 4A5(RCB0557) |