Reference - Detail
| RRC ID | 44129 |
|---|---|
| Author | Awale S, Ueda JY, Athikomkulchai S, Dibwe DF, Abdelhamed S, Yokoyama S, Saiki I, Miyatake R. |
| Title | Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac. |
| Journal | J Nat Prod |
| Abstract |
Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions. |
| Volume | 75(11) |
| Pages | 1999-2002 |
| Published | 2012-11-26 |
| DOI | 10.1021/np300596c |
| PMID | 23092429 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology* Cyclohexenes / chemistry Cyclohexenes / isolation & purification* Cyclohexenes / pharmacology* Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms / drug therapy Plant Stems / chemistry Thailand Uvaria / chemistry* |
| IF | 3.782 |
| Times Cited | 15 |
| WOS Category | PLANT SCIENCES PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Google+ |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | PANC-1(RCB2095) |