論文 - 詳細
| RRC ID | 44149 |
|---|---|
| 著者 | Iwasaki T, Yamakawa M, Asaoka A, Kawano T, Ishibashi J. |
| タイトル | Anti-angiogenesis activities of novel peptide complexes: mitochondria-disruptive 9mer peptides conjugated with the integrin alpha V beta 3-homing cyclic RGD motif. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
RGD peptides are popular drug delivery tools in treating integrin αVβ3-expressing malignant tumors and tumor vasculature cells. We investigated the specific delivery and pharmacological potential of enantiomeric mitochondria-disruptive peptides (RLYLRIGRR-NH(2), RLRLRIGRR-NH(2), ALYLAIRRR-NH(2), and RLLLRIGRR-NH(2)) after conjugation with an integrin αVβ3-homing peptide, cyclic pentameric RGD peptide. The cyclic RGD-conjugated mitochondria-disruptive peptides exhibited specific internalization, apoptosis induction, and cytotoxicity against integrin αVβ3-high-expressing human umbilical vein endothelial cells. Our findings indicate that these novel peptide complexes might prove good anti-angiogenesis reagents. |
| 巻・号 | 76(11) |
| ページ | 2044-8 |
| 公開日 | 2012-1-1 |
| DOI | 10.1271/bbb.120397 |
| PII | DN/JST.JSTAGE/bbb/120397 |
| PMID | 23132564 |
| MeSH | Amino Acid Motifs Amino Acid Sequence Angiogenesis Inhibitors / chemistry Angiogenesis Inhibitors / metabolism Angiogenesis Inhibitors / pharmacology Angiogenesis Inhibitors / toxicity Animals Apoptosis / drug effects COS Cells Cell Line, Tumor Chlorocebus aethiops Drug Carriers / metabolism* Gene Expression Regulation / drug effects Humans Integrin alphaVbeta3 / metabolism* Membrane Potential, Mitochondrial / drug effects Mitochondria / drug effects* Mitochondria / metabolism Oligopeptides / chemistry* Oligopeptides / metabolism Oligopeptides / pharmacology* Oligopeptides / toxicity Peptides, Cyclic / metabolism* Protein Transport |
| IF | 1.516 |
| 引用数 | 1 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |