論文 - 詳細
| RRC ID | 44166 |
|---|---|
| 著者 | Matsubara D, Kanai Y, Ishikawa S, Ohara S, Yoshimoto T, Sakatani T, Oguni S, Tamura T, Kataoka H, Endo S, Murakami Y, Aburatani H, Fukayama M, Niki T. |
| タイトル | Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad. |
| ジャーナル | J Thorac Oncol |
| Abstract |
Rearranged during transfection (RET) fusions have been newly identified in approximately 1% of patients with primary lung tumors. However, patient-derived lung cancer cell lines harboring RET fusions have not yet been established or identified, and therefore, the effectiveness of an RET inhibitor on lung tumors with endogenous RET fusion has not yet been studied. In this study, we report identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line LC-2/ad. LC-2/ad showed distinctive sensitivity to the RET inhibitor, vandetanib, among 39 non-small lung cancer cell lines. The xenograft tumor of LC-2/ad showed cribriform acinar structures, a morphologic feature of primary RET fusion-positive lung adenocarcinomas. LC-2/ad cells could provide useful resources to analyze molecular functions of RET-fusion protein and its response to RET inhibitors. |
| 巻・号 | 7(12) |
| ページ | 1872-1876 |
| 公開日 | 2012-12-1 |
| DOI | 10.1097/JTO.0b013e3182721ed1 |
| PII | S1556-0864(15)33173-7 |
| PMID | 23154560 |
| MeSH | Adenocarcinoma / drug therapy Adenocarcinoma / genetics* Adenocarcinoma / pathology Animals Antineoplastic Combined Chemotherapy Protocols / pharmacology Blotting, Western Carcinoma, Non-Small-Cell Lung / drug therapy Carcinoma, Non-Small-Cell Lung / genetics* Carcinoma, Non-Small-Cell Lung / pathology Cell Proliferation / drug effects Cytoskeletal Proteins / genetics* Female Gefitinib Humans Immunoenzyme Techniques Lung Neoplasms / drug therapy Lung Neoplasms / genetics* Lung Neoplasms / pathology Mice Mice, Inbred NOD Mice, SCID Oncogene Proteins, Fusion / genetics* Phosphorylation / drug effects Piperidines / administration & dosage Proto-Oncogene Proteins c-ret / genetics* Quinazolines / administration & dosage RNA, Messenger / genetics Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Transplantation, Heterologous Tumor Cells, Cultured |
| IF | 13.357 |
| 引用数 | 53 |
| WOS 分野 | RESPIRATORY SYSTEM ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |