論文 - 詳細
| RRC ID | 44221 |
|---|---|
| 著者 | Yagi S, Matsuda M, Kiyokawa E. |
| タイトル | Chimaerin suppresses Rac1 activation at the apical membrane to maintain the cyst structure. |
| ジャーナル | PLoS One |
| Abstract |
Epithelial organs are made of a well-polarized monolayer of epithelial cells, and their morphology is maintained strictly for their proper functions. Previously, we showed that Rac1 activation is suppressed at the apical membrane in the mature organoid, and that such spatially biased Rac1 activity is required for the polarity maintenance. Here we identify Chimaerin, a GTPase activating protein for Rac1, as a suppressor of Rac1 activity at the apical membrane. Depletion of Chimaerin causes over-activation of Rac1 at the apical membrane in the presence of hepatocyte growth factor (HGF), followed by luminal cell accumulation. Importantly, Chimaerin depletion did not inhibit extension formation at the basal membrane. These observations suggest that Chimaerin functions as the apical-specific Rac1 GAP to maintain epithelial morphology. |
| 巻・号 | 7(12) |
| ページ | e52258 |
| 公開日 | 2012-1-1 |
| DOI | 10.1371/journal.pone.0052258 |
| PII | PONE-D-12-24587 |
| PMID | 23284959 |
| PMC | PMC3527519 |
| MeSH | Animals Cell Line Chimerin 1 / metabolism Chimerin Proteins / metabolism* Dogs Hepatocyte Growth Factor / pharmacology Microscopy, Confocal Polymerase Chain Reaction rac1 GTP-Binding Protein / metabolism* |
| IF | 2.74 |
| 引用数 | 11 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MDCK(RCB0995) |