論文 - 詳細
| RRC ID | 44246 |
|---|---|
| 著者 | Yoshida H, Watanabe W, Oomagari H, Tsuruta E, Shida M, Kurokawa M. |
| タイトル | Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes. |
| ジャーナル | J Nutr Biochem |
| Abstract |
Toll-like receptors (TLRs) were recently shown to be involved in obesity-induced inflammation in adipose tissue, which contributes to the development of insulin resistance and type 2 diabetes. Thus, the appropriate regulation of TLR expression or activation is an important strategy for improving obesity-related diseases. In this report, we show that naringenin, a citrus flavonoid, inhibits TLR2 expression during adipocyte differentiation. This effect is mediated in part through peroxisome proliferator-activated receptor γ activation. In addition, naringenin suppresses TLR2 expression induced by the co-culture of differentiated adipocytes and macrophages and also inhibits tumor necrosis factor-α (TNF-α)-induced TLR2 expression by inhibiting the activation of nuclear factor-κB and c-Jun NH2-terminal kinase pathways in differentiated adipocytes. Furthermore, naringenin decreases TLR2 expression in adipose tissue of high-fat diet-fed mice. These results are correlated with the improvement of hyperglycemia and the suppression of inflammatory mediators, including TNF-α and monocyte chemotactic protein-1. Taken together, these data suggest that naringenin exhibits anti-inflammatory properties, presumably by inhibiting TLR2 expression in adipocytes. Our findings suggest a molecular mechanism by which naringenin exerts beneficial effects against obesity-related diseases. |
| 巻・号 | 24(7) |
| ページ | 1276-84 |
| 公開日 | 2013-7-1 |
| DOI | 10.1016/j.jnutbio.2012.10.003 |
| PII | S0955-2863(12)00272-0 |
| PMID | 23333096 |
| MeSH | 3T3-L1 Cells Adipocytes / cytology Adipocytes / drug effects* Adipocytes / metabolism Animals Cell Differentiation Citrus / chemistry* Coculture Techniques Flavanones / pharmacology* MAP Kinase Kinase 4 / metabolism Male Mice Mice, Inbred C57BL NF-kappa B / metabolism PPAR gamma / metabolism Toll-Like Receptor 2 / antagonists & inhibitors* Toll-Like Receptor 2 / metabolism Tumor Necrosis Factor-alpha / antagonists & inhibitors |
| IF | 4.873 |
| 引用数 | 43 |
| WOS 分野 | NUTRITION & DIETETICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |