RRC ID 44248
Author Dutot M, Vincent J, Martin-Brisac N, Fabre I, Grasmick C, Rat P.
Title Ocular cytotoxicity evaluation of medical devices such as contact lens solutions and benefits of a rinse step in cleaning procedure.
Journal ALTEX
Abstract Contact lens care solutions are known to have toxic effects on the ocular surface. The ISO 10993-5 standard describes test methods to assess the cytotoxicity of medical devices, but it needs some improvements to discriminate contact lens care multipurpose solutions. First we evaluated the biological hazards associated with the use of ophthalmic solutions, running a collaborative study with the French medical agency to propose adapted tools to study contact lens care solutions' ocular cytotoxicity (human cell line, short incubation times, and no dilution of solutions to test). Then we took into account the potential risk of these ophthalmic solutions adsorbed on contact lenses and released on the ocular surface, highlighting the addition of a rinse step with unpreserved marine solution in the contact lens cleaning procedure to avoid side effects of contact lens care solutions.
Volume 30(1)
Pages 41-9
Published 2013
DOI 10.14573/altex.2013.1.041
PMID 23338805
MeSH Animal Testing Alternatives / methods* Animals Cell Survival Conjunctiva / cytology Contact Lens Solutions / standards Contact Lens Solutions / toxicity* Contact Lenses Cornea / cytology Epithelial Cells / drug effects* Eye Diseases / chemically induced* Feeder Cells Humans
IF 5.232
Times Cited 1
Human and Animal Cells