論文 - 詳細
| RRC ID | 44250 |
|---|---|
| 著者 | Norikura T, Fujiwara K, Yanai T, Sano Y, Sato T, Tsunoda T, Kushibe K, Todate A, Morinaga Y, Iwai K, Matsue H. |
| タイトル | p-terphenyl derivatives from the mushroom Thelephora aurantiotincta suppress the proliferation of human hepatocellular carcinoma cells via iron chelation. |
| ジャーナル | J Agric Food Chem |
| Abstract |
A novel 2',3'-dihydroxy-p-terphenyl derivative, thelephantin O (TO), which has cancer-selective cytotoxicity, was isolated. This study investigated the underlying basis of the cytotoxicity of 2',3'-dihydroxy-p-terphenyl compounds in view of their ability to chelate metal ions. FeCl(2) significantly reduced TO-induced cytotoxicity, whereas several other salts of transition metals and alkaline-earth metals did not. A structure-activity relationship study using newly synthesized p-terphenyl derivatives revealed that o-dihydroxy substitution of the central benzene ring was necessary for both the cytotoxicity and Fe(2+) chelation of the compounds. Real-time PCR array and cell cycle analysis revealed that the TO-induced cytotoxicity was attributed to cell cycle arrest at the G1 phase via well-known cell cycle-mediated genes. The TO-induced changes in the cell cycle and gene expression were completely reversed by the addition of FeCl(2). Thus, it was concluded that Fe(2+) chelation occurs upstream in the pivotal pathway of 2',3'-dihydroxy-p-terphenyl-induced inhibition of cancer cell proliferation. |
| 巻・号 | 61(6) |
| ページ | 1258-64 |
| 公開日 | 2013-2-13 |
| DOI | 10.1021/jf3041098 |
| PMID | 23339435 |
| MeSH | Agaricales / chemistry* Carcinoma, Hepatocellular / metabolism Carcinoma, Hepatocellular / physiopathology* Cell Line, Tumor Cell Proliferation / drug effects* Down-Regulation / drug effects G1 Phase Humans Iron / metabolism* Liver Neoplasms / metabolism Liver Neoplasms / physiopathology* Molecular Structure Terphenyl Compounds / chemistry Terphenyl Compounds / isolation & purification Terphenyl Compounds / pharmacology* |
| IF | 4.192 |
| 引用数 | 12 |
| WOS 分野 | AGRICULTURE, MULTIDISCIPLINARY FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2 |