Reference - Detail
| RRC ID | 44284 |
|---|---|
| Author | Nakamura S, Nakashima S, Oda Y, Yokota N, Fujimoto K, Matsumoto T, Ohta T, Ogawa K, Maeda S, Nishida S, Matsuda H, Yoshikawa M. |
| Title | Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B. |
| Journal | Bioorg Med Chem |
| Abstract |
A methanolic extract and its ethyl acetate-soluble fraction from Sri Lankan curry-leaf, the leaves of Murraya koenigii, inhibited melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Two new carbazole alkaloids, karapinchamines A and B, were isolated from the ethyl acetate-soluble fraction together with 12 known carbazole alkaloids. The structures of karapinchamines A and B were determined by physicochemical analyses. The principal alkaloid constituents were found to display potent melanogenesis inhibitory activity. The structural requirements of the carbazole alkaloids for melanogenesis inhibitory activity were discussed. |
| Volume | 21(5) |
| Pages | 1043-9 |
| Published | 2013-3-1 |
| DOI | 10.1016/j.bmc.2013.01.012 |
| PII | S0968-0896(13)00041-2 |
| PMID | 23376010 |
| MeSH | Acetates / chemistry Alkaloids / chemistry* Alkaloids / isolation & purification Alkaloids / pharmacology* Animals Carbazoles / chemistry* Carbazoles / isolation & purification Carbazoles / pharmacology Cell Differentiation / drug effects Cell Line, Tumor Chemical Fractionation Gene Expression Regulation / drug effects Magnetic Resonance Spectroscopy Melanins / metabolism Mice Molecular Conformation Murraya / chemistry* Plant Extracts / chemistry* Plant Extracts / pharmacology* Plant Leaves / chemistry |
| IF | 3.073 |
| Times Cited | 36 |
| WOS Category | CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | B16 melanoma 4A5(RCB0557) |