Reference - Detail
RRC ID | 44285 |
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Author | Zhao S, Liu H, Liu Y, Wu J, Wang C, Hou X, Chen X, Yang G, Zhao L, Che H, Bi Y, Wang H, Peng F, Ai J. |
Title | miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells. |
Journal | Cancer Lett |
Abstract |
Glioblastomas rely mainly on aerobic glycolysis to sustain proliferation and growth; however, little is known about the regulatory mechanisms of metabolism in glioblastoma stem cells. We show that miR-143 is significantly down-regulated in glioma tissues and glioblastoma stem-like cells (GSLCs), while miR-143 over-expression inhibits glycolysis by directly targeting hexokinase 2, and promotes differentiation of GSLCs. Moreover, miR-143 inhibits proliferation of GSLCs under hypoxic conditions and decreases tumor formation capacity of GSLCs in vivo. We also show that a combination of miR-143 and 2-DG, a widely used glycolysis inhibitor, has synergistic effects against GSLCs. miR-143 is a potential therapeutic target for glioblastoma treatment. |
Volume | 333(2) |
Pages | 253-60 |
Published | 2013-6-10 |
DOI | 10.1016/j.canlet.2013.01.039 |
PII | S0304-3835(13)00085-2 |
PMID | 23376635 |
MeSH | Animals Base Sequence Cell Differentiation / genetics Cell Hypoxia / genetics Cell Line, Tumor Deoxyglucose / pharmacology Female Glioblastoma / drug therapy Glioblastoma / genetics Glioblastoma / pathology Glioma / genetics* Glioma / pathology* Glycolysis / genetics Humans Mice Mice, Inbred BALB C MicroRNAs / genetics* Molecular Sequence Data Neoplastic Stem Cells / drug effects Neoplastic Stem Cells / pathology* Rats |
IF | 7.36 |
Times Cited | 52 |
WOS Category | ONCOLOGY |
Resource | |
Human and Animal Cells | U-87 MG(RCB0429) C6(RCB2854) |