Reference - Detail
| RRC ID | 44308 |
|---|---|
| Author | Gottschalk C, Damuzzo V, Gotot J, Kroczek RA, Yagita H, Murphy KM, Knolle PA, Ludwig-Portugall I, Kurts C. |
| Title | Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens. |
| Journal | J Am Soc Nephrol |
| Abstract |
Although the spleen is a major site where immune tolerance to circulating innocuous antigens occurs, the kidney also contributes. Circulating antigens smaller than albumin are constitutively filtered and concentrated in the kidney and reach the renal lymph node by lymphatic drainage, where resident dendritic cells (DCs) capture them and induce tolerance of specific cytotoxic T cells through unknown mechanisms. Here, we found that the coinhibitory cell surface receptor programmed death 1 (PD-1) on cytotoxic T cells mediates to their tolerance. Renal lymph node DCs of the CD8(+) XCR1(+) subset, which depend on the transcription factor Batf3, expressed the PD-1 cognate ligand PD-L1. Batf3-dependent DCs in the renal lymph node presented antigen that had been concentrated in the kidney and used PD-L1 to induce apoptosis of cytotoxic T cells. In contrast, T cell tolerance in the spleen was independent of PD-1, PD-L1, and Batf3. In summary, these results clarify how the kidney/renal lymph node system tolerizes the immune system against circulating innocuous antigens. |
| Volume | 24(4) |
| Pages | 543-9 |
| Published | 2013-3-1 |
| DOI | 10.1681/ASN.2012101022 |
| PII | ASN.2012101022 |
| PMID | 23411785 |
| PMC | PMC3609142 |
| MeSH | Animals Antigens / blood Antigens / immunology* Basic-Leucine Zipper Transcription Factors / genetics Basic-Leucine Zipper Transcription Factors / metabolism* Dendritic Cells / immunology* Dendritic Cells / metabolism Immune Tolerance / immunology* Kidney / immunology* Kidney / metabolism Lymph Nodes / immunology* Lymph Nodes / metabolism Mice Mice, Mutant Strains Programmed Cell Death 1 Receptor / immunology Programmed Cell Death 1 Receptor / metabolism Repressor Proteins / genetics Repressor Proteins / metabolism* T-Lymphocytes, Cytotoxic / immunology T-Lymphocytes, Cytotoxic / metabolism |
| IF | 9.274 |
| Times Cited | 28 |
| WOS Category | UROLOGY & NEPHROLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MIH5 |