論文 - 詳細
| RRC ID | 44333 |
|---|---|
| 著者 | Miyatake Y, Oliveira AL, Jarboui MA, Ota S, Tomaru U, Teshima T, Hall WW, Kasahara M. |
| タイトル | Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. |
| ジャーナル | Am J Pathol |
| Abstract |
Adult T-cell leukemia/lymphoma (ATL) is a highly invasive and intractable T-cell malignancy caused by human T-cell leukemia virus-1 infection. We demonstrate herein that normal tissue-derived epithelial cells (NECs) exert protective effects on the survival of leukemic cells, which may partially account for high resistance to antileukemic therapies in patients with ATL. Viral gene-silenced, ATL-derived cell lines (ATL cells) dramatically escaped from histone deacetylase inhibitor-induced apoptosis by direct co-culture with NECs. Adhesions to NECs suppressed p21(Cip1) expression and increased a proportion of resting G0/G1 phase cells in trichostatin A (TSA)-treated ATL cells. ATL cells adhering to NECs down-regulated CD25 expression and enhanced vimentin expression, suggesting that most ATL cells acquired a quiescent state by cell-cell interactions with NECs. ATL cells adhering to NECs displayed highly elevated expression of the cancer stem cell marker CD44. Blockade of CD44 signaling diminished the NEC-conferred resistance of ATL cells to TSA-induced apoptosis. Co-culture with NECs also suppressed the expression of NKG2D ligands on TSA-treated ATL cells, resulting in decreased natural killer cell-mediated cytotoxicity. Combined evidence suggests that interactions with normal epithelial cells augment the resistance of ATL cells to TSA-induced apoptosis and facilitate immune evasion by ATL cells. |
| 巻・号 | 182(5) |
| ページ | 1832-42 |
| 公開日 | 2013-5-1 |
| DOI | 10.1016/j.ajpath.2013.01.015 |
| PII | S0002-9440(13)00099-0 |
| PMID | 23474084 |
| MeSH | Adult Apoptosis / drug effects Cell Adhesion / drug effects Cell Communication / drug effects Cell Cycle / drug effects Cell Line, Tumor Cell Separation Cell Survival / drug effects Coculture Techniques Cytoprotection* / drug effects Epithelial Cells / drug effects Epithelial Cells / metabolism Epithelial Cells / pathology* Histone Deacetylase Inhibitors / pharmacology Humans Hyaluronan Receptors / metabolism Hydroxamic Acids / pharmacology Intracellular Space / drug effects Intracellular Space / metabolism Leukemia-Lymphoma, Adult T-Cell / pathology* Ligands NK Cell Lectin-Like Receptor Subfamily K / metabolism Tumor Stem Cell Assay |
| IF | 3.491 |
| 引用数 | 14 |
| WOS 分野 | PATHOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 1C3IKEI(RCB0797) |