論文 - 詳細
| RRC ID | 44343 |
|---|---|
| 著者 | Jia W, Kidoya H, Yamakawa D, Naito H, Takakura N. |
| タイトル | Galectin-3 accelerates M2 macrophage infiltration and angiogenesis in tumors. |
| ジャーナル | Am J Pathol |
| Abstract |
It is widely accepted that robust invasion of tumor-associated macrophages resembling M2 macrophage correlates with disease aggressiveness by affecting cancer cell invasion, metastasis, and angiogenesis. Many chemokines that induce migration of macrophages have been identified during inflammatory responses; however, further precise analysis of macrophage migration in the tumor microenvironment is required. Here, we analyzed the function of galectin-3 (Gal-3; gene LGALS3, alias Gal3) for macrophage chemotaxis using Gal3(-/-) mice as hosts, and a tumor allograft model. We engineered a concentration gradient of Gal-3 produced by the tumor. In this model, we found that macrophage infiltration was enhanced in tumors developing in these Gal3(-/-) mice relative to the Gal3(+/+) animals. This was accompanied by enhanced tumor angiogenesis and tumor growth in Gal3(-/-) mice. We found that macrophages of the M2 phenotype were dominant in infiltrates in the Gal3(-/-) mice and that they expressed only low levels of Gal-3. Gal3 knockdown by siRNA in macrophages resulted in enhanced chemotaxis. These data suggest that M2-like macrophages migrate into the tumor along a Gal-3 gradient and that high-level Gal-3 expression in the tumor results in acceleration of angiogenesis and tumor growth. Therefore, Gal-3 could be a potential target for the development of new treatments to inhibit tumor growth. |
| 巻・号 | 182(5) |
| ページ | 1821-31 |
| 公開日 | 2013-5-1 |
| DOI | 10.1016/j.ajpath.2013.01.017 |
| PII | S0002-9440(13)00101-6 |
| PMID | 23499465 |
| MeSH | Animals Bone Marrow Cells / metabolism Bone Marrow Cells / pathology Carcinogenesis / metabolism Carcinogenesis / pathology Cell Line Cell Movement Cell Proliferation Galectin 3 / deficiency Galectin 3 / metabolism* Humans Macrophages / metabolism* Macrophages / pathology* Mice Mice, Inbred C57BL Mice, Knockout Neoplasm Transplantation Neoplasms / blood supply* Neoplasms / metabolism Neoplasms / pathology* Neovascularization, Pathologic / metabolism* Neovascularization, Pathologic / pathology* |
| IF | 3.491 |
| 引用数 | 41 |
| WOS 分野 | PATHOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | J774 |