RRC ID |
44398
|
Author |
Uchida M, Oyanagi E, Miyachi M, Yamauchi A, Yano H.
|
Title |
Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells.
|
Journal |
J Immunol Methods
|
Abstract |
We investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged myoblasts using in vitro models of muscle injury. We found that: 1) the chemotactic activity of macrophages toward areas of damaged myoblasts might be induced more by live myoblasts than dead ones, 2) the chemotactic activity of macrophages is not due to velocity, but depends on the directionality toward damaged myoblast cells, and 3) macrophage differentiation strongly influence the chemotactic activity toward damaged myoblast cells through the expression of CCR2 and/or F-actin.
|
Volume |
393(1-2)
|
Pages |
61-9
|
Published |
2013-7-31
|
DOI |
10.1016/j.jim.2013.04.007
|
PII |
S0022-1759(13)00128-2
|
PMID |
23603617
|
MeSH |
Actins / immunology
Actins / metabolism
Animals
Cell Differentiation / immunology
Cell Line
Chemokine CCL2 / immunology
Chemokine CCL2 / metabolism
Chemotaxis / immunology*
Macrophages / immunology*
Macrophages / metabolism
Macrophages / pathology*
Mice
Muscle, Skeletal / immunology
Muscle, Skeletal / metabolism
Muscle, Skeletal / pathology
Muscular Diseases / immunology
Muscular Diseases / metabolism
Muscular Diseases / pathology
Myoblasts / immunology*
Myoblasts / metabolism
Myoblasts / pathology*
Receptors, CCR2 / immunology
Receptors, CCR2 / metabolism
|
IF |
1.901
|
Times Cited |
2
|
WOS Category
|
IMMUNOLOGY
BIOCHEMICAL RESEARCH METHODS
|
Resource |
Human and Animal Cells |
C2C12(RCB0987)
J774 |