論文 - 詳細
| RRC ID | 44441 |
|---|---|
| 著者 | Kikuchi T, Takebayashi M, Shinto M, Yamada T, Tanaka R. |
| タイトル | Three new multiflorane-type triterpenes from pumpkin (Cucurbita maxima) seeds. |
| ジャーナル | Molecules |
| Abstract |
Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3a-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells. |
| 巻・号 | 18(5) |
| ページ | 5568-79 |
| 公開日 | 2013-5-14 |
| DOI | 10.3390/molecules18055568 |
| PII | molecules18055568 |
| PMID | 23673529 |
| PMC | PMC6270121 |
| MeSH | Animals Cucurbita / chemistry* Cytotoxins* / chemistry Cytotoxins* / isolation & purification Cytotoxins* / pharmacology Dose-Response Relationship, Drug HL-60 Cells Humans Melanoma / drug therapy* Melanoma / metabolism Melanoma / pathology Mice Seeds / chemistry* Triterpenes* / chemistry Triterpenes* / isolation & purification Triterpenes* / pharmacology |
| IF | 3.267 |
| 引用数 | 9 |
| WOS 分野 | CHEMISTRY, ORGANIC |
| リソース情報 | |
| ヒト・動物細胞 | |