RRC ID 44462
Author Hu W, Pei H, Li H, Ding N, He J, Wang J, Furusawa Y, Hirayama R, Matsumoto Y, Liu C, Li Y, Kawata T, Zhou G.
Title Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures.
Journal J Radiat Res
Abstract High atomic number and high-energy (HZE) particles in deep space are of low abundance but substantially contribute to the biological effects of space radiation. Shielding is so far the most effective way to partially protect astronauts from these highly penetrating particles. However, simulated calculations and measurements have predicted that secondary particles resulting from the shielding of cosmic rays produce a significant fraction of the total dose and dose equivalent. In this study, we investigated the biological effects of secondary radiation with two cell types, and with cells exposed in different phases of the cell cycle, by comparing the biological effects of a 200 MeV/u iron beam with a shielded beam in which the energy of the iron ion beam was decreased from 500 MeV/u to 200 MeV/u with PMMA, polyethylene (PE), or aluminum. We found that beam shielding resulted in increased induction of 53BP1 foci and micronuclei in a cell-type-dependent manner compared with the unshielded 200 MeV/u Fe ion beam. These findings provide experimental proof that the biological effects of secondary particles resulting from the interaction between HZE particles and shielding materials should be considered in shielding design.
Volume 55(1)
Pages 10-6
Published 2014-1-1
DOI 10.1093/jrr/rrt078
PII rrt078
PMID 23728321
PMC PMC3885111
MeSH Cell Cycle / genetics Cell Cycle / radiation effects* Cell Line, Tumor Cell Survival / genetics Cell Survival / radiation effects* Cosmic Radiation* DNA Damage / genetics* Equipment Design Equipment Failure Analysis Heavy Ions Humans Intracellular Signaling Peptides and Proteins / genetics* Iron Radioisotopes Linear Energy Transfer / radiation effects Micronuclei, Chromosome-Defective / drug effects* Radiation Protection / instrumentation* Scattering, Radiation Tumor Suppressor p53-Binding Protein 1
IF 1.95
Times Cited 2
WOS Category BIOLOGY RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Resource
Human and Animal Cells MRC-5