Reference - Detail
| RRC ID | 44585 |
|---|---|
| Author | Pepić I, Lovrić J, Cetina-Čižmek B, Reichl S, Filipović-Grčić J. |
| Title | Toward the practical implementation of eye-related bioavailability prediction models. |
| Journal | Drug Discov Today |
| Abstract |
The development and registration of reformulated ophthalmic products (OPs) requires eye-related bioavailability (BA) assessments. Common BA algorithms associated with other routes of application, such as the oral route, cannot be easily applied to eye-related BA testing. Here, we provide an analysis of the current literature and suggestions for further directions in the development of high-capacity, cost-effective, and highly predictive nonclinical models of eye-related drug BA. One, or a combination of these models, has the potential for routine use in research laboratories and/or the pharmaceutical industry to overcome various obstacles in reformulated OP development and registration. |
| Volume | 19(1) |
| Pages | 31-44 |
| Published | 2014-1-1 |
| DOI | 10.1016/j.drudis.2013.08.002 |
| PII | S1359-6446(13)00265-1 |
| PMID | 23948143 |
| MeSH | Administration, Ophthalmic Animals Biological Availability Eye / drug effects* Eye / metabolism* Humans Models, Biological* Permeability / drug effects Pharmaceutical Preparations / administration & dosage* Pharmaceutical Preparations / metabolism* |
| IF | 7.321 |
| Times Cited | 25 |
| WOS Category | PHARMACOLOGY & PHARMACY |
| Resource | |
| Human and Animal Cells | HCE-T(RCB2280) |