論文 - 詳細
| RRC ID | 44586 |
|---|---|
| 著者 | Ninomiya K, Kawabata S, Tashita H, Shimizu N. |
| タイトル | Ultrasound-mediated drug delivery using liposomes modified with a thermosensitive polymer. |
| ジャーナル | Ultrason Sonochem |
| Abstract |
Ultrasound-mediated drug delivery was established using liposomes that were modified with the thermosensitive polymer (TSP) poly(NIPMAM-co-NIPAM), which sensitized the liposomes to high temperatures. TSP-modified liposomes (TSP liposomes) released encapsulated calcein under 1 MHz ultrasound irradiation at 0.5 W/cm(2) for 120 s as well as the case under incubation at 42 °C for 15 min. In addition, uptake of the drug released from TSP liposomes by cancer cells was enhanced by ultrasound irradiation. In a cell injury assay using doxorubicin (DOX)-loaded TSP liposomes and ultrasound irradiation, cell viability of HepG2 cells at 6 h after ultrasound irradiation (1 MHz, 0.5 W/cm(2) for 30 s) with DOX-loaded TSP liposomes (TSP/lipid ratio=1) was 60%, which was significantly lower than that of the control conditions such as DOX-loaded TSP liposomes alone and DOX-loaded intact liposomes under ultrasound irradiation. |
| 巻・号 | 21(1) |
| ページ | 310-6 |
| 公開日 | 2014-1-1 |
| DOI | 10.1016/j.ultsonch.2013.07.014 |
| PII | S1350-4177(13)00167-3 |
| PMID | 23948493 |
| MeSH | Acrylic Resins / chemistry* Biological Transport Drug Delivery Systems / methods* Hep G2 Cells Humans Liposomes / chemistry* Polymers / chemistry* Temperature* Ultrasonics* |
| IF | 6.513 |
| 引用数 | 44 |
| WOS 分野 | ACOUSTICS CHEMISTRY, MULTIDISCIPLINARY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2(RCB1648) |