| RRC ID |
44586
|
| 著者 |
Ninomiya K, Kawabata S, Tashita H, Shimizu N.
|
| タイトル |
Ultrasound-mediated drug delivery using liposomes modified with a thermosensitive polymer.
|
| ジャーナル |
Ultrason Sonochem
|
| Abstract |
Ultrasound-mediated drug delivery was established using liposomes that were modified with the thermosensitive polymer (TSP) poly(NIPMAM-co-NIPAM), which sensitized the liposomes to high temperatures. TSP-modified liposomes (TSP liposomes) released encapsulated calcein under 1 MHz ultrasound irradiation at 0.5 W/cm(2) for 120 s as well as the case under incubation at 42 °C for 15 min. In addition, uptake of the drug released from TSP liposomes by cancer cells was enhanced by ultrasound irradiation. In a cell injury assay using doxorubicin (DOX)-loaded TSP liposomes and ultrasound irradiation, cell viability of HepG2 cells at 6 h after ultrasound irradiation (1 MHz, 0.5 W/cm(2) for 30 s) with DOX-loaded TSP liposomes (TSP/lipid ratio=1) was 60%, which was significantly lower than that of the control conditions such as DOX-loaded TSP liposomes alone and DOX-loaded intact liposomes under ultrasound irradiation.
|
| 巻・号 |
21(1)
|
| ページ |
310-6
|
| 公開日 |
2014-1-1
|
| DOI |
10.1016/j.ultsonch.2013.07.014
|
| PII |
S1350-4177(13)00167-3
|
| PMID |
23948493
|
| MeSH |
Acrylic Resins / chemistry*
Biological Transport
Drug Delivery Systems / methods*
Hep G2 Cells
Humans
Liposomes / chemistry*
Polymers / chemistry*
Temperature*
Ultrasonics*
|
| IF |
6.513
|
| 引用数 |
44
|
|
WOS 分野
|
ACOUSTICS
CHEMISTRY, MULTIDISCIPLINARY
|
| リソース情報 |
| ヒト・動物細胞 |
|
