Reference - Detail
| RRC ID | 44631 |
|---|---|
| Author | Ueda H, Takeuchi A, Wako T. |
| Title | Activation of immune responses in mice by an oral administration of bunching onion (Allium fistulosum) mucus. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
Bunching onion [Allium fistulosum L. (Liliaceae)] secretes mucus in the cavities of its green leaves. The effects of the mucus, which is consumed as food, were examined. The mucus augmented the production of tumor necrosis factor (TNF)-α and monocyte chemotactic protein (MCP)-1 from RAW 264 cells and of interleukin (IL)-12 from J774.1 cells; however, extracts from green leaves and white sheaths did not. An oral administration of this mucus to mice augmented the immune functions of peritoneal cells by increasing TNF-α and IL-12 production and phagocytosis. It also augmented interferon (IFN)-γ production from spleen cells and natural killer (NK) activity. These results suggest that an oral administration of the A. fistulosum mucus can enhance natural immunity. |
| Volume | 77(9) |
| Pages | 1809-13 |
| Published | 2013-1-1 |
| DOI | 10.1271/bbb.130084 |
| PII | DN/JST.JSTAGE/bbb/130084 |
| PMID | 24018671 |
| MeSH | Administration, Oral Allium / chemistry* Animals Cell Line Immunologic Factors / administration & dosage* Immunologic Factors / pharmacology* Interleukin-12 / biosynthesis Macrophages / drug effects Macrophages / immunology Macrophages / metabolism Male Mice Mice, Inbred ICR Plant Extracts / administration & dosage* Plant Extracts / pharmacology* Plant Leaves / chemistry Tumor Necrosis Factor-alpha / biosynthesis |
| IF | 1.516 |
| Times Cited | 7 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) J774.1 YAC-1 |