論文 - 詳細
| RRC ID | 44645 |
|---|---|
| 著者 | Nakayama T, Takeuchi D, Matsumura T, Akeda Y, Fujinaga Y, Oishi K. |
| タイトル | Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections. |
| ジャーナル | Microb Pathog |
| Abstract |
Streptococcus suis is an emerging zoonotic agent. This study aimed to investigate whether S. suis is likely to translocate across the intestines of human hosts who have liver disease and/or consume alcohol. Both the alcoholism and cirrhosis models exhibited high mRNA expression of TGF and collagen1, but only the cirrhosis model had fibrosis in the liver. After both models were infected with S. suis, significantly different concentrations of S. suis were detected in the blood and brains of the alcoholism model (Blood: 36.4%; Brain: 31.8%) and the cirrhosis model (Blood: 62.5%; Brain: 62.5%) compared to the concentrations in the healthy mice (Blood: 15.4%; Brain: 0%). Trans-epithelial electrical resistance (TER) was used to examine the Caco-2 cells in the in vitro that had an S. suis infection combined with 1% ethanol. Although the ethanol did not influence the Caco-2 cells' barriers, it did rapidly decrease the barriers' TER value and then their E-cadherin compared to the infected Caco-2 cells without the ethanol treatment. Immunofluorescence also indicated that the barriers of the Caco-2 cells treated with ethanol were disrupted and that S. suis translocated from the apical to the basolateral side. This study demonstrated that alcohol consumption helped S. suis to translocate. |
| 巻・号 | 65 |
| ページ | 14-20 |
| 公開日 | 2013-12-1 |
| DOI | 10.1016/j.micpath.2013.08.006 |
| PII | S0882-4010(13)00119-8 |
| PMID | 24036179 |
| MeSH | Alcohol Drinking / adverse effects* Animals Caco-2 Cells Cadherins / metabolism Collagen Type I / biosynthesis Collagen Type I / genetics Epithelial Cells / drug effects Epithelial Cells / metabolism Ethanol / pharmacology Female Humans Intestines / microbiology* Liver Cirrhosis, Alcoholic / immunology* Mice Mice, Inbred A Streptococcal Infections / immunology* Streptococcal Infections / microbiology Streptococcus suis* Transforming Growth Factor beta1 / biosynthesis Transforming Growth Factor beta1 / genetics |
| IF | 2.914 |
| 引用数 | 8 |
| WOS 分野 | MICROBIOLOGY IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CACO-2(RCB0988) |