RRC ID 44680
著者 Kamitakahara M, Uno Y, Ioku K.
タイトル Behavior of osteoblast-like cells on calcium-deficient hydroxyapatite ceramics composed of particles with different shapes and sizes.
ジャーナル J Mater Sci Mater Med
Abstract In designing the biomaterials, it is important to control their surface morphologies, because they affect the interactions between the materials and cells. We previously reported that porous calcium-deficient hydroxyapatite (HA) ceramics composed of rod-like particles had advantages over sintered porous HA ceramics; however, the effects of the surface morphology of calcium-deficient HA ceramics on cell behavior have remained unclear. Using a hydrothermal process, we successfully prepared porous calcium-deficient HA ceramics with different surface morphologies, composed of plate-like particles of 200-300, 500-800 nm, or 2-3 μm in width and rod-like particles of 1 or 3-5 μm in width, respectively. The effects of these surface morphologies on the behavior of osteoblast-like cells were examined. Although the numbers of cells adhered to the ceramic specimens did not differ significantly among the specimens, the proliferation rates of cells on the ceramics decreased with decreasing particle size. Our results reveal that controlling the surface morphology that is governed by particle shape and size is important for designing porous calcium-deficient HA ceramics.
巻・号 25(1)
ページ 239-45
公開日 2014-1-1
DOI 10.1007/s10856-013-5063-6
PMID 24101185
MeSH 3T3 Cells Animals Bone Regeneration Bone Substitutes / chemistry* Calcium / chemistry* Cell Proliferation Ceramics / chemistry* Durapatite / chemistry* Materials Testing Mice Microscopy, Electron, Scanning Nanoparticles / chemistry Nanoparticles / ultrastructure Osteoblasts / cytology* Particle Size Porosity
IF 2.489
引用数 5
WOS 分野 ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS
リソース情報
ヒト・動物細胞 MC3T3-E1(RCB1126)