| RRC ID |
44720
|
| 著者 |
Kimura R, Rokkaku T, Takeda S, Senba M, Mori N.
|
| タイトル |
Cytotoxic effects of fucoidan nanoparticles against osteosarcoma.
|
| ジャーナル |
Mar Drugs
|
| Abstract |
In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relative to native fucoidan, were confirmed in vivo using a xenograft osteosarcoma model. Caco-2 cell transport studies showed that permeation of nanoparticle fucoidan was higher than native fucoidan. The higher bioactivity and superior bioavailability of nanoparticle fucoidan could potentially be utilized to develop novel therapies for osteosarcoma.
|
| 巻・号 |
11(11)
|
| ページ |
4267-78
|
| 公開日 |
2013-10-30
|
| DOI |
10.3390/md11114267
|
| PII |
md11114267
|
| PMID |
24177673
|
| PMC |
PMC3853727
|
| MeSH |
Animals
Biological Availability
Caco-2 Cells
Carcinogenesis / drug effects
Cell Line, Tumor
Female
Humans
Lung / drug effects
Mice
Mice, Inbred C3H
Nanoparticles / administration & dosage*
Osteosarcoma / drug therapy*
Permeability
Polysaccharides / pharmacology*
|
| IF |
4.073
|
| 引用数 |
30
|
|
WOS 分野
|
CHEMISTRY, MEDICINAL
|
| リソース情報 |
| ヒト・動物細胞 |
CACO-2(RCB0988) |
