論文 - 詳細
| RRC ID | 44720 |
|---|---|
| 著者 | Kimura R, Rokkaku T, Takeda S, Senba M, Mori N. |
| タイトル | Cytotoxic effects of fucoidan nanoparticles against osteosarcoma. |
| ジャーナル | Mar Drugs |
| Abstract |
In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relative to native fucoidan, were confirmed in vivo using a xenograft osteosarcoma model. Caco-2 cell transport studies showed that permeation of nanoparticle fucoidan was higher than native fucoidan. The higher bioactivity and superior bioavailability of nanoparticle fucoidan could potentially be utilized to develop novel therapies for osteosarcoma. |
| 巻・号 | 11(11) |
| ページ | 4267-78 |
| 公開日 | 2013-10-30 |
| DOI | 10.3390/md11114267 |
| PII | md11114267 |
| PMID | 24177673 |
| PMC | PMC3853727 |
| MeSH | Animals Biological Availability Caco-2 Cells Carcinogenesis / drug effects Cell Line, Tumor Female Humans Lung / drug effects Mice Mice, Inbred C3H Nanoparticles / administration & dosage* Osteosarcoma / drug therapy* Permeability Polysaccharides / pharmacology* |
| IF | 4.073 |
| 引用数 | 30 |
| WOS 分野 | CHEMISTRY, MEDICINAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CACO-2(RCB0988) |