| RRC ID |
44776
|
| Author |
Tatsuta T, Hosono M, Takahashi K, Omoto T, Kariya Y, Sugawara S, Hakomori S, Nitta K.
|
| Title |
Sialic acid-binding lectin (leczyme) induces apoptosis to malignant mesothelioma and exerts synergistic antitumor effects with TRAIL.
|
| Journal |
Int J Oncol
|
| Abstract |
Malignant mesothelioma is a highly aggressive tumor with poor prognosis. An effective drug for treatment of malignant mesothelioma is greatly needed. Sialic acid-binding lectin (SBL) isolated from oocytes of Rana catesbeiana is a multifunctional protein which has lectin activity, ribonuclease activity and antitumor activity, so it could be developed as a new type of anticancer drug. The validity of SBL for treatment of malignant mesothelioma was assessed using three malignant mesotheliomas and a non-malignant mesothlial cell line. Effectiveness of combinatorial treatment of SBL and tumor necrosis factor-related apoptosis inducing ligand (TRAIL) was also elucidated and characterized. SBL induced tumor-selective cytotoxicity that was attributed to induction of apoptosis. Combinatorial treatment of SBL and TRAIL showed synergistic apoptosis-inducing effect. Additional experiments revealed that Bid was the mediating molecule for the synergistic effect in SBL and TRAIL. These results suggested that SBL could be a promising candidate for the therapeutics for malignant mesothelioma. Furthermore, the combinatorial treatment of SBL and TRAIL could be an effective regimen against malignant mesothelioma.
|
| Volume |
44(2)
|
| Pages |
377-84
|
| Published |
2014-2-1
|
| DOI |
10.3892/ijo.2013.2192
|
| PMID |
24297392
|
| PMC |
PMC3898873
|
| MeSH |
Amphibian Proteins / pharmacology*
Apoptosis / drug effects*
BH3 Interacting Domain Death Agonist Protein / metabolism
Blotting, Western
Cell Proliferation
Drug Combinations
Drug Synergism*
Humans
Lectins / pharmacology*
Lung Neoplasms / metabolism
Lung Neoplasms / pathology*
Lung Neoplasms / prevention & control
Membrane Potential, Mitochondrial
Mesothelioma / metabolism
Mesothelioma / pathology*
Mesothelioma / prevention & control
Mesothelioma, Malignant
Mitochondria / metabolism
Ribonucleases / pharmacology*
TNF-Related Apoptosis-Inducing Ligand / pharmacology*
Tumor Cells, Cultured
|
| IF |
3.899
|
| Times Cited |
14
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
ACC-MESO-1(RCB2292)
ACC-MESO-4(RCB2293) |
