論文 - 詳細
| RRC ID | 44826 |
|---|---|
| 著者 | Shakya B, Yadav PN, Ueda JY, Awale S. |
| タイトル | Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents. |
| ジャーナル | Bioorg Med Chem Lett |
| Abstract |
Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer. |
| 巻・号 | 24(2) |
| ページ | 458-61 |
| 公開日 | 2014-1-15 |
| DOI | 10.1016/j.bmcl.2013.12.044 |
| PII | S0960-894X(13)01416-9 |
| PMID | 24380769 |
| MeSH | Antineoplastic Agents / chemistry* Antineoplastic Agents / therapeutic use Cell Line, Tumor Dose-Response Relationship, Drug Drug Screening Assays, Antitumor / methods Formamides / chemistry* Formamides / therapeutic use Humans Pancreatic Neoplasms / drug therapy* Pancreatic Neoplasms / pathology Pyridines / chemistry* Pyridines / therapeutic use Thiosemicarbazones / chemistry* Thiosemicarbazones / therapeutic use |
| IF | 2.572 |
| 引用数 | 13 |
| WOS 分野 | CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) |