RRC ID 44843
Author Zhu F, Asada T, Sato A, Koi Y, Nishiwaki H, Tamura H.
Title Rosmarinic acid extract for antioxidant, antiallergic, and α-glucosidase inhibitory activities, isolated by supramolecular technique and solvent extraction from Perilla leaves.
Journal J Agric Food Chem
Abstract Rosmarinic acid extract with potent biological activities was successfully isolated by supramolecular technique and solvent extraction from Perilla leaves. By the supramolecular complex which was formed from flavocommelin and Perilla leaf extract as initial materials, the supernatant containing rosmarinic acid was isolated. Rosmarinic acid extract (62.9 ± 4.5% purity) was partly purified by partitioning ethyl acetate and water. Rosmarinic acid extract exhibited high total phenolic content of 433.9 ± 58.6 μg/mg of gallic acid equivalent, effective DPPH radical scavenging activity (SC50 of 5.5 ± 0.2 μg/mL), antiallergic activity (IC50 of 52.9 ± 6.7 μg/mL), and α-glucosidase inhibitory activity (IC50 of 0.23 ± 0.01 mg/mL). Rosmarinic acid extract shows high potential for diabetes mellitus and allergy treatments by inhibiting α-glucosidase activity and measuring β-hexosaminidase, related to life-style disease.
Volume 62(4)
Pages 885-92
Published 2014-1-29
DOI 10.1021/jf404318j
PMID 24400891
MeSH Anti-Allergic Agents / pharmacology* Antioxidants / pharmacology* Chromatography, High Pressure Liquid / methods Cinnamates / isolation & purification Cinnamates / pharmacology* Depsides / isolation & purification Depsides / pharmacology* Enzyme Inhibitors / pharmacology Glycoside Hydrolase Inhibitors* Mast Cells / drug effects Mast Cells / metabolism Perilla frutescens / chemistry* Plant Extracts / chemistry Plant Extracts / pharmacology Plant Leaves / chemistry* beta-N-Acetylhexosaminidases / metabolism
IF 4.192
Times Cited 70
Human and Animal Cells RBL 2H3(RCB2782)