論文 - 詳細
| RRC ID | 44843 |
|---|---|
| 著者 | Zhu F, Asada T, Sato A, Koi Y, Nishiwaki H, Tamura H. |
| タイトル | Rosmarinic acid extract for antioxidant, antiallergic, and α-glucosidase inhibitory activities, isolated by supramolecular technique and solvent extraction from Perilla leaves. |
| ジャーナル | J Agric Food Chem |
| Abstract |
Rosmarinic acid extract with potent biological activities was successfully isolated by supramolecular technique and solvent extraction from Perilla leaves. By the supramolecular complex which was formed from flavocommelin and Perilla leaf extract as initial materials, the supernatant containing rosmarinic acid was isolated. Rosmarinic acid extract (62.9 ± 4.5% purity) was partly purified by partitioning ethyl acetate and water. Rosmarinic acid extract exhibited high total phenolic content of 433.9 ± 58.6 μg/mg of gallic acid equivalent, effective DPPH radical scavenging activity (SC50 of 5.5 ± 0.2 μg/mL), antiallergic activity (IC50 of 52.9 ± 6.7 μg/mL), and α-glucosidase inhibitory activity (IC50 of 0.23 ± 0.01 mg/mL). Rosmarinic acid extract shows high potential for diabetes mellitus and allergy treatments by inhibiting α-glucosidase activity and measuring β-hexosaminidase, related to life-style disease. |
| 巻・号 | 62(4) |
| ページ | 885-92 |
| 公開日 | 2014-1-29 |
| DOI | 10.1021/jf404318j |
| PMID | 24400891 |
| MeSH | Anti-Allergic Agents / pharmacology* Antioxidants / pharmacology* Chromatography, High Pressure Liquid / methods Cinnamates / isolation & purification Cinnamates / pharmacology* Depsides / isolation & purification Depsides / pharmacology* Enzyme Inhibitors / pharmacology Glycoside Hydrolase Inhibitors* Mast Cells / drug effects Mast Cells / metabolism Perilla frutescens / chemistry* Plant Extracts / chemistry Plant Extracts / pharmacology Plant Leaves / chemistry* beta-N-Acetylhexosaminidases / metabolism |
| IF | 4.192 |
| 引用数 | 70 |
| WOS 分野 | AGRICULTURE, MULTIDISCIPLINARY FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RBL 2H3(RCB2782) |