| RRC ID |
44915
|
| Author |
Balasubramanian S, Girija AR, Nagaoka Y, Iwai S, Suzuki M, Kizhikkilot V, Yoshida Y, Maekawa T, Nair SD.
|
| Title |
Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia.
|
| Journal |
Int J Nanomedicine
|
| Abstract |
The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU]) and magnetic nanoparticles encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon magnetic hyperthermia, we could harness the advantages of incorporating magnetic nanoparticles that synergistically acted with the drugs to destroy cancer cells within a very short period of time. The remarkable multimodal efficacy attained by this therapeutic nanoformulation offers the potential for targeting, imaging, and treatment of cancer within a short period of time (120 minutes) by initiating early and late apoptosis.
|
| Volume |
9
|
| Pages |
437-59
|
| Published |
2014-1-1
|
| DOI |
10.2147/IJN.S49882
|
| PII |
ijn-9-437
|
| PMID |
24531392
|
| PMC |
PMC3891567
|
| MeSH |
Animals
Antineoplastic Agents / administration & dosage
Apoptosis / drug effects
Cell Line
Combined Modality Therapy
Curcumin / administration & dosage*
Drug Carriers / chemistry
Fluorouracil / administration & dosage*
Folic Acid / chemistry
Humans
Hyperthermia, Induced / methods
Lactic Acid / chemistry
MCF-7 Cells
Magnetite Nanoparticles / administration & dosage*
Magnetite Nanoparticles / chemistry
Mice
Nanoconjugates / administration & dosage
Nanoconjugates / chemistry
Nanomedicine
Nanotechnology
Neoplasms / drug therapy
Neoplasms / pathology
Neoplasms / therapy*
Polyglycolic Acid / chemistry
Polylactic Acid-Polyglycolic Acid Copolymer
Transferrin / chemistry
|
| IF |
5.115
|
| Times Cited |
73
|
| Resource |
| Human and Animal Cells |
MCF7(RCB1904)
L929 |
