Reference - Detail
| RRC ID | 44915 |
|---|---|
| Author | Balasubramanian S, Girija AR, Nagaoka Y, Iwai S, Suzuki M, Kizhikkilot V, Yoshida Y, Maekawa T, Nair SD. |
| Title | Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia. |
| Journal | Int J Nanomedicine |
| Abstract |
The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU]) and magnetic nanoparticles encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon magnetic hyperthermia, we could harness the advantages of incorporating magnetic nanoparticles that synergistically acted with the drugs to destroy cancer cells within a very short period of time. The remarkable multimodal efficacy attained by this therapeutic nanoformulation offers the potential for targeting, imaging, and treatment of cancer within a short period of time (120 minutes) by initiating early and late apoptosis. |
| Volume | 9 |
| Pages | 437-59 |
| Published | 2014-1-1 |
| DOI | 10.2147/IJN.S49882 |
| PII | ijn-9-437 |
| PMID | 24531392 |
| PMC | PMC3891567 |
| MeSH | Animals Antineoplastic Agents / administration & dosage Apoptosis / drug effects Cell Line Combined Modality Therapy Curcumin / administration & dosage* Drug Carriers / chemistry Fluorouracil / administration & dosage* Folic Acid / chemistry Humans Hyperthermia, Induced / methods Lactic Acid / chemistry MCF-7 Cells Magnetite Nanoparticles / administration & dosage* Magnetite Nanoparticles / chemistry Mice Nanoconjugates / administration & dosage Nanoconjugates / chemistry Nanomedicine Nanotechnology Neoplasms / drug therapy Neoplasms / pathology Neoplasms / therapy* Polyglycolic Acid / chemistry Polylactic Acid-Polyglycolic Acid Copolymer Transferrin / chemistry |
| IF | 5.115 |
| Times Cited | 73 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MCF7(RCB1904) L929 |