論文 - 詳細
| RRC ID | 45071 |
|---|---|
| 著者 | Clarke MR, Imhoff FM, Baird SK. |
| タイトル | Mesenchymal stem cells inhibit breast cancer cell migration and invasion through secretion of tissue inhibitor of metalloproteinase-1 and -2. |
| ジャーナル | Mol Carcinog |
| Abstract |
Mesenchymal stem cells (MSCs) form part of tumor stroma, and are typically considered to be pro-tumorigenic, promoting continuing tumor growth and metastasis. Here, we describe a mechanism by which MSCs may be anti-tumorigenic, through inhibition of breast cancer cell migration and invasion, an important part of metastasis. MDA-MB-231 and T47D cells were co-cultured in a Transwell insert above MSCs or MSC conditioned media and their migration or invasion through Matrigel measured. The conditioned media was found to inhibit breast cancer cell movement. TIMP-1 and TIMP-2, inhibitors of matrix metalloproteinases (MMPs), were identified as candidates for this inhibition and enhanced secretion of MMPs was not sufficient to counter the anti-migratory effects of TIMP expression. Inhibition of TIMP activity showed that TIMP-1 and TIMP-2 together were largely responsible for the reduction of migration and invasion by MSCs. Therefore, MSCs may play anti-tumorigenic, anti-metastatic roles in tumor development, with the overall outcome dependent upon the balance of pro-and anti-tumorigenic molecules secreted. |
| 巻・号 | 54(10) |
| ページ | 1214-9 |
| 公開日 | 2015-10-1 |
| DOI | 10.1002/mc.22178 |
| PMID | 24819588 |
| MeSH | Breast Neoplasms / metabolism* Breast Neoplasms / pathology* Cell Line, Tumor Cell Movement / physiology* Coculture Techniques / methods Collagen / metabolism Culture Media, Conditioned / metabolism Drug Combinations Female Humans Laminin / metabolism Mesenchymal Stem Cells / metabolism* Mesenchymal Stem Cells / pathology* Proteoglycans / metabolism Tissue Inhibitor of Metalloproteinase-1 / metabolism* Tissue Inhibitor of Metalloproteinase-2 / metabolism* |
| IF | 3.825 |
| 引用数 | 36 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | UBE6T-7(RCB2157) |