論文 - 詳細
| RRC ID | 45074 |
|---|---|
| 著者 | Lu F, Nabeshima T. |
| タイトル | A highly selective and sensitive turn-on chemodosimeter for hypochlorous acid based on an iridium(III) complex and its application to bioimaging. |
| ジャーナル | Dalton Trans |
| Abstract |
A novel and easily accessible luminescent iridium(iii) complex [Ir(tpy)2(N^N)]PF6 (, tpy = 2-(p-tolyl)pyridine, N^N = 4-[(4-amino-3-nitrophenoxy)-methylene]-4'-methyl-2,2'-bipyridine) for the sensing of HOCl has been designed and synthesized. The detection strategy is based on the HOCl-promoted cleavage of the PET quenching 4-amino-3-nitrophenyloxy moiety of the weakly emissive complex , which gives rise to a highly luminescent complex [Ir(tpy)2(N^N')]PF6 (, N^N' = 4-hydroxymethyl-4'-methyl-2,2'-bipyridine). Comparisons of the absorption, emission and mass spectra of in the absence and presence of HOCl have all confirmed the transformation of to . Titration and competition experiments have revealed high sensitivity and high selectivity of for HOCl, respectively. Significantly, the feasibility of the sensor under physiological conditions enables the successful luminescent imaging of HOCl in HeLa cells. |
| 巻・号 | 43(25) |
| ページ | 9529-36 |
| 公開日 | 2014-7-7 |
| DOI | 10.1039/c4dt00616j |
| PMID | 24828854 |
| MeSH | 2,2'-Dipyridyl / chemistry* Biosensing Techniques / methods* Coordination Complexes / chemistry* HeLa Cells Humans Hypochlorous Acid / analysis* Hypochlorous Acid / metabolism Luminescent Agents / chemistry* Luminescent Measurements Optical Imaging / methods* Ruthenium / chemistry* |
| IF | 4.174 |
| 引用数 | 27 |
| WOS 分野 | CHEMISTRY, INORGANIC & NUCLEAR |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) |