論文 - 詳細
| RRC ID | 45075 |
|---|---|
| 著者 | Kiyofuji A, Yui K, Takahashi K, Osada K. |
| タイトル | Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes. |
| ジャーナル | J Oleo Sci |
| Abstract |
Xanthohumol is a major prenylated, hydrophobic flavonoid found in the female inflorescences of the hop plant (Humulus lupulus L.). In this study, we examined the effects of xanthohumol-rich hop extract containing 17.8% xanthohumol and 12.4% isoxanthohumol on the differentiation and adipogenesis of 3T3L1 cells. We observed that the extract inhibited the differentiation of 3T3L1 cells and intracellular fat droplets via the regulation of adipogenic factors such as the peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein alpha, and adipocyte fatty acid-binding protein. |
| 巻・号 | 63(6) |
| ページ | 593-7 |
| 公開日 | 2014-1-1 |
| DOI | 10.5650/jos.ess14009 |
| PII | DN/JST.JSTAGE/jos/ess14009 |
| PMID | 24829131 |
| MeSH | Adipocytes / cytology* Adipocytes / metabolism Adipogenesis / drug effects* Adipogenesis / genetics Animals Anti-Obesity Agents CCAAT-Enhancer-Binding Protein-alpha / metabolism Cell Differentiation / drug effects* Cell Line Fatty Acid-Binding Proteins / metabolism Fibroblasts / cytology* Flavonoids / isolation & purification Flavonoids / pharmacology* Humulus / chemistry* Lipid Metabolism / drug effects Lipid Metabolism / genetics Mice PPAR gamma / metabolism Plant Extracts / isolation & purification Plant Extracts / pharmacology* Propiophenones / isolation & purification Propiophenones / pharmacology* Xanthones / isolation & purification Xanthones / pharmacology |
| IF | 1.304 |
| 引用数 | 10 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| リソース情報 | |
| ヒト・動物細胞 | A549 |