Reference - Detail
| RRC ID | 45162 |
|---|---|
| Author | Orabi MA, Taniguchi S, Sakagami H, Yoshimura M, Yoshida T, Hatano T. |
| Title | Hydrolyzable tannins of tamaricaceous plants. V. Structures of monomeric-trimeric tannins and cytotoxicity of macrocyclic-type tannins isolated from Tamarix nilotica (1). |
| Journal | J Nat Prod |
| Abstract |
Three new ellagitannin monomers, nilotinins M5-M7 (1-3), a dimer, nilotinin D10 (4), and a trimer, nilotinin T1 (5), together with three known dimers, hirtellin D (7) and tamarixinins B (8) and C (9), and a trimer, hirtellin T2 (6), were isolated from Tamarix nilotica dried leaves. The structures of the tannins were elucidated by intensive spectroscopic methods and chemical conversions into known tannins. The new trimer (5) is a unique macrocyclic type whose monomeric units are linked together by an isodehydrodigalloyl and two dehydrodigalloyl moieties. Additionally, dimeric and trimeric macrocyclic-type tannins isolated from T. nilotica in this study were assessed for possible cytotoxic activity against four human tumor cell lines. Tumor-selective cytotoxicities of the tested compounds were higher than those of synthetic and natural potent cytotoxic compounds, including polyphenols, and comparable with those of 5-fluorouracil and melphalan. |
| Volume | 76(5) |
| Pages | 947-56 |
| Published | 2013-5-24 |
| DOI | 10.1021/np4001625 |
| PMID | 23675651 |
| MeSH | Antineoplastic Agents, Phytogenic* / chemistry Antineoplastic Agents, Phytogenic* / isolation & purification Antineoplastic Agents, Phytogenic* / pharmacology Drug Screening Assays, Antitumor Egypt Fluorouracil / pharmacology Humans Hydrolyzable Tannins* / chemistry Hydrolyzable Tannins* / isolation & purification Hydrolyzable Tannins* / pharmacology Melphalan / pharmacology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Leaves / chemistry Polyphenols / pharmacology Tamaricaceae / chemistry* |
| Times Cited | 10 |
| Resource | |
| Human and Animal Cells | HL60 |