論文 - 詳細
| RRC ID | 45182 |
|---|---|
| 著者 | Nishiura H, Yamanegi K, Kawabe M, Kato-Kogoe N, Yamada N, Nakasho K. |
| タイトル | Annexin A3 plays a role in cytoplasmic calcium oscillation by extracellular calcium in the human promyelocytic leukemia HL-60 cells differentiated by phorbol-12-myristate-13-acetate. |
| ジャーナル | Exp Mol Pathol |
| Abstract |
The roles of annexin A3 (ANXA3) in macrophages are not fully understood. In contrast to C5a, we have demonstrated that C-terminal ribosomal protein S19 (RP S19)-tagged S-tagged C5a (S-tagged C5a/RP S19) raises an alternative cytoplasmic calcium oscillation by extracellular calcium during macrophage migration into apoptotic cells. We here differentiated human promyelocytic leukemia HL-60 cells bearing with either control sense RNA and shRNA for ANXA3 mRNA or a vector cDNA with or without ANXA3 cDNA into macrophage-like cells by phorbol-12-myristate-13-acetate and found that a fluorescence ratio (340 nm/380 nm) upon the S-tagged C5a/RP S19-induced alternative cytoplasmic calcium oscillation by extracellular calcium was an equilateral association with a dose of ANXA3. Moreover, the ANXA3-dependent modification was partially reflected upon the S-tagged C5a-induced classical cytoplasmic calcium oscillation by both intracellular calcium and extracellular calcium. ANXA3 seems to extend the C5aR-mediated cytoplasmic calcium oscillation by extracellular calcium at least in the HL-60 macrophage-like cells. |
| 巻・号 | 97(2) |
| ページ | 241-6 |
| 公開日 | 2014-10-1 |
| DOI | 10.1016/j.yexmp.2014.07.010 |
| PII | S0014-4800(14)00107-5 |
| PMID | 25036403 |
| MeSH | Annexin A3 / genetics Annexin A3 / metabolism* Calcium / pharmacology Calcium Signaling* Cell Differentiation HL-60 Cells Humans Macrophages / drug effects Macrophages / metabolism Receptor, Anaphylatoxin C5a / genetics Receptor, Anaphylatoxin C5a / metabolism Tetradecanoylphorbol Acetate / pharmacology |
| IF | 2.28 |
| 引用数 | 2 |
| WOS 分野 | PATHOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60 |