RRC ID 45197
Author Zhu B, Luo SC, Zhao H, Lin HA, Sekine J, Nakao A, Chen C, Yamashita Y, Yu HH.
Title Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer.
Journal Nat Commun
Abstract Although electrically stimulated neurite outgrowth on bioelectronic devices is a promising means of nerve regeneration, immunogenic scar formation can insulate electrodes from targeted cells and tissues, thereby reducing the lifetime of the device. Ideally, an electrode material capable of electrically interfacing with neurons selectively and efficiently would be integrated without being recognized by the immune system and minimize its response. Here we develop a cell membrane-mimicking conducting polymer possessing several attractive features. This polymer displays high resistance towards nonspecific enzyme/cell binding and recognizes targeted cells specifically to allow intimate electrical communication over long periods of time. Its low electrical impedance relays electrical signals efficiently. This material is capable to integrate biochemical and electrical stimulation to promote neural cellular behaviour. Neurite outgrowth is enhanced greatly on this new conducting polymer; in addition, electrically stimulated secretion of proteins from primary Schwann cells can also occur on it.
Volume 5
Pages 4523
Published 2014-7-25
DOI 10.1038/ncomms5523
PII ncomms5523
PMID 25060339
MeSH Animals Biocompatible Materials / chemistry* Biomimetic Materials / chemistry* Cell Adhesion Electric Conductivity Electric Stimulation Equipment Design Mice NIH 3T3 Cells Nerve Growth Factor / metabolism Neurites / physiology* Neurons / physiology PC12 Cells Peptides / chemistry Polymers / chemistry Rats Schwann Cells
IF 11.878
Times Cited 81
Human and Animal Cells