論文 - 詳細
| RRC ID | 45197 |
|---|---|
| 著者 | Zhu B, Luo SC, Zhao H, Lin HA, Sekine J, Nakao A, Chen C, Yamashita Y, Yu HH. |
| タイトル | Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer. |
| ジャーナル | Nat Commun |
| Abstract |
Although electrically stimulated neurite outgrowth on bioelectronic devices is a promising means of nerve regeneration, immunogenic scar formation can insulate electrodes from targeted cells and tissues, thereby reducing the lifetime of the device. Ideally, an electrode material capable of electrically interfacing with neurons selectively and efficiently would be integrated without being recognized by the immune system and minimize its response. Here we develop a cell membrane-mimicking conducting polymer possessing several attractive features. This polymer displays high resistance towards nonspecific enzyme/cell binding and recognizes targeted cells specifically to allow intimate electrical communication over long periods of time. Its low electrical impedance relays electrical signals efficiently. This material is capable to integrate biochemical and electrical stimulation to promote neural cellular behaviour. Neurite outgrowth is enhanced greatly on this new conducting polymer; in addition, electrically stimulated secretion of proteins from primary Schwann cells can also occur on it. |
| 巻・号 | 5 |
| ページ | 4523 |
| 公開日 | 2014-7-25 |
| DOI | 10.1038/ncomms5523 |
| PII | ncomms5523 |
| PMID | 25060339 |
| MeSH | Animals Biocompatible Materials / chemistry* Biomimetic Materials / chemistry* Cell Adhesion Electric Conductivity Electric Stimulation Equipment Design Mice NIH 3T3 Cells Nerve Growth Factor / metabolism Neurites / physiology* Neurons / physiology PC12 Cells Peptides / chemistry Polymers / chemistry Rats Schwann Cells |
| IF | 12.121 |
| 引用数 | 81 |
| WOS 分野 | ENGINEERING, BIOMEDICAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) NIH3T3 |