| RRC ID |
45259
|
| 著者 |
Maenz S, Kunisch E, Mühlstädt M, Böhm A, Kopsch V, Bossert J, Kinne RW, Jandt KD.
|
| タイトル |
Enhanced mechanical properties of a novel, injectable, fiber-reinforced brushite cement.
|
| ジャーナル |
J Mech Behav Biomed Mater
|
| Abstract |
Injectable, brushite-forming calcium phosphate cements (CPCs) have great potential as bone replacement materials due to enhanced degradability and long-term inclusion in bone remodeling. However, the use of such brushite-forming CPCs in load-bearing areas is limited by their low mechanical strength. One approach to overcome this limitation is the use of reinforcing fibers. Thus, an injectable, biodegradable, brushite-forming CPC based on beta-tricalcium phosphate/phosphoric acid with fiber reinforcement was developed for minimally invasive surgery. The fibers (diameter 25 µm; length 0.25, 1 or 2mm) were extruded from poly(l-lactide-co-glycolide) acid (PLGA) and added to the CPC (2.5, 5 or 7.5% (w/w)). Independent of the fiber content, injectability of the CPC was retained up to a fiber length of 1mm. The addition of all PLGA fiber types increased diametral tensile strength, biaxial flexural strength, and flexural strength by up to 25% (p ≤ 0.05 for the diametral tensile strength for the CPC with 5% (w/w) 1mm fibers and the biaxial flexural strength of the CPC with 5% (w/w) 0.25 mm fibers). In contrast, the work of fracture strongly and significantly increased (p<0.01) by up to 12.5-fold. At constant fiber content, the mechanical properties of the fiber-reinforced CPC were mostly augmented with increasing fiber length. Also, the addition of PLGA fibers to the brushite-forming CPC (up to 7.5% (w/w)) only transiently delayed cell growth and did not decrease cell viability. Fiber reinforcement of CPCs thus augments their mechanical strength while preserving the injectability and biocompatibility required for their application in modern surgery.
|
| 巻・号 |
39
|
| ページ |
328-38
|
| 公開日 |
2014-11-1
|
| DOI |
10.1016/j.jmbbm.2014.07.028
|
| PII |
S1751-6161(14)00234-3
|
| PMID |
25171749
|
| MeSH |
Animals
Biocompatible Materials / chemistry*
Bone Cements / chemistry*
Bone Substitutes
Calcium Phosphates / chemistry*
Cell Proliferation
Cell Survival
Elastic Modulus
Lactic Acid / chemistry*
Materials Testing
Mice
Minimally Invasive Surgical Procedures
Polyglycolic Acid / chemistry*
Polylactic Acid-Polyglycolic Acid Copolymer
Powders
Stress, Mechanical
Tensile Strength
X-Ray Diffraction
|
| IF |
3.372
|
| 引用数 |
29
|
|
WOS 分野
|
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
| リソース情報 |
| ヒト・動物細胞 |
ATDC5(RCB0565) |
