RRC ID 45262
Author Lei F, Haque R, Xiong X, Song J.
Title Modulation of autoimmune diseases by iPS cells.
Journal Methods Mol Biol
Abstract Autoimmune disease is typically caused by the activated self-reacted immune cells. The mainstream treatment to autoimmune disorders is composed of different mechanisms of immunosuppression. In recent years, a new subtype of T cells called regulatory T (Treg) cells have been identified to maintain the immune homeostasis in terms of suppressing the activated immune components. According to this discovery, it is suggested that treating autoimmune patients by supplementing Treg cells would be a good choice. However, due to their natural scarcity, it is difficult to isolate a desired number of Treg for this therapeutical approach. Here, we report that by using stem cells, especially the induced pluripotent stem (iPS) cells, we are able to generate a significant amount of Treg cells for the autoimmune prevention and treatment.
Volume 1213
Pages 365-77
Published 2014-1-1
DOI 10.1007/978-1-4939-1453-1_30
PMID 25173398
PMC PMC5656293
MeSH Adoptive Transfer Animals Arthritis, Experimental Autoimmune Diseases / immunology* Autoimmune Diseases / metabolism* Cell Differentiation Cell Line Disease Models, Animal Flow Cytometry Fluorescent Antibody Technique Forkhead Transcription Factors / metabolism Gene Expression Genetic Vectors / genetics Immune Tolerance Immunohistochemistry Immunomodulation* Immunophenotyping Induced Pluripotent Stem Cells / cytology Induced Pluripotent Stem Cells / metabolism* Male Mice Retroviridae / genetics Transduction, Genetic
Times Cited 2
WOS Category MEDICINE, RESEARCH & EXPERIMENTAL CELL & TISSUE ENGINEERING BIOCHEMICAL RESEARCH METHODS BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Human and Animal Cells iPS-MEF-Ng-20D-17(APS0001)