Reference - Detail
| RRC ID | 45305 |
|---|---|
| Author | Mitsuhashi S, Shindo C, Shigetomi K, Miyamoto T, Ubukata M. |
| Title | (+)-Epogymnolactam, a novel autophagy inducer from mycelial culture of Gymnopus sp. |
| Journal | Phytochemistry |
| Abstract |
Mushrooms, including Ganoderma lucidum, have been used as a potential source of therapeutic compounds, and an autophagy inducer would be useful for treatment of diverse diseases in human. Reported here is a full account of screening, isolation, structural determination, and biological activity of an autophagy inducer, (+)-epogymnolactam (1) from a mycelial culture of a Gymnopus sp. strain. Its structure was elucidated by HR-ESI-MS, NMR, and its plus sign by specific rotation. It exists as a tautomeric mixture of 1a and 1b in MeOH. The major tautomer of 1 is (1R,5S)-4-butyl-4-hydroxy-3-aza-6-oxa-bicyclo[3.1.0]hexan-2-one (1a), and the minor tautomeric form is (2R,3S)-3-pentanoyloxirane-2-carboxamide (1b). |
| Volume | 114 |
| Pages | 163-7 |
| Published | 2015-6-1 |
| DOI | 10.1016/j.phytochem.2014.08.012 |
| PII | S0031-9422(14)00327-6 |
| PMID | 25242622 |
| MeSH | Agaricales / chemistry* Autophagy / drug effects* Bridged Bicyclo Compounds, Heterocyclic / chemistry Bridged Bicyclo Compounds, Heterocyclic / isolation & purification* Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Stereoisomerism |
| IF | 3.044 |
| Times Cited | 8 |
| WOS Category | PLANT SCIENCES BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | NIH/3T3(RCB2767) |