Reference - Detail
| RRC ID | 45409 |
|---|---|
| Author | Nakagawa Y, Nakasako S, Ohta S, Ito T. |
| Title | A biocompatible calcium salt of hyaluronic acid grafted with polyacrylic acid. |
| Journal | Carbohydr Polym |
| Abstract |
We have synthesized hyaluronic acid (HA) grafted with polyacrylic acid (PAA) via controlled radical polymerization (CRP) in aqueous media. The grafted HA (HA-g-PAA) showed slow degradation by hyaluronidase compared with unmodified HA as a result of the steric hindrance produced by grafted PAA, and PAA was detached by hydrolysis and enzymatic degradation by lipase. It formed an insoluble salt immediately after mixing with Ca(2+) by the binding between grafted PAA and Ca(2+). Both HA-g-PAA and its salt showed good biocompatibility, especially to mesothelial cells in vitro. Finally, they were administered into mice subcutaneously and intraperitoneally. The residue of the material was observed 7 days after subcutaneous administration, while the material was almost cleared from the peritoneum 7 days after intraperitoneal administration with or without Ca(2+). HA-g-PAA is expected to be applicable to medical uses such as drug delivery in the peritoneum and for materials preventing peritoneal adhesion. |
| Volume | 117 |
| Pages | 43-53 |
| Published | 2015-3-6 |
| DOI | 10.1016/j.carbpol.2014.09.037 |
| PII | S0144-8617(14)00934-5 |
| PMID | 25498607 |
| MeSH | Acrylic Resins / chemistry* Animals Biocompatible Materials / chemistry* Biocompatible Materials / pharmacology* Calcium / chemistry* Cell Line Cell Survival / drug effects Humans Hyaluronic Acid / chemistry* Hyaluronic Acid / pharmacology* Mice Peritoneum / drug effects Salts / chemistry* |
| IF | 7.182 |
| Times Cited | 16 |
| WOS Category | CHEMISTRY, ORGANIC POLYMER SCIENCE CHEMISTRY, APPLIED |
| Resource | |
| Human and Animal Cells | NIH/3T3(RCB2767) |