論文 - 詳細
| RRC ID | 45497 |
|---|---|
| 著者 | Tinganelli W, Durante M, Hirayama R, Krämer M, Maier A, Kraft-Weyrather W, Furusawa Y, Friedrich T, Scifoni E. |
| タイトル | Kill-painting of hypoxic tumours in charged particle therapy. |
| ジャーナル | Sci Rep |
| Abstract |
Solid tumours often present regions with severe oxygen deprivation (hypoxia), which are resistant to both chemotherapy and radiotherapy. Increased radiosensitivity as a function of the oxygen concentration is well described for X-rays. It has also been demonstrated that radioresistance in anoxia is reduced using high-LET radiation rather than conventional X-rays. However, the dependence of the oxygen enhancement ratio (OER) on radiation quality in the regions of intermediate oxygen concentrations, those normally found in tumours, had never been measured and biophysical models were based on extrapolations. Here we present a complete survival dataset of mammalian cells exposed to different ions in oxygen concentration ranging from normoxia (21%) to anoxia (0%). The data were used to generate a model of the dependence of the OER on oxygen concentration and particle energy. The model was implemented in the ion beam treatment planning system to prescribe uniform cell killing across volumes with heterogeneous radiosensitivity. The adaptive treatment plans have been validated in two different accelerator facilities, using a biological phantom where cells can be irradiated simultaneously at three different oxygen concentrations. We thus realized a hypoxia-adapted treatment plan, which will be used for painting by voxel of hypoxic tumours visualized by functional imaging. |
| 巻・号 | 5 |
| ページ | 17016 |
| 公開日 | 2015-11-24 |
| DOI | 10.1038/srep17016 |
| PII | srep17016 |
| PMID | 26596243 |
| PMC | PMC4657060 |
| MeSH | Animals CHO Cells Cell Hypoxia Cell Survival / radiation effects Cricetinae Cricetulus Humans Neoplasms / radiotherapy* Oxygen / physiology Radiation Tolerance Radiotherapy Planning, Computer-Assisted Radiotherapy, Image-Guided |
| IF | 3.998 |
| 引用数 | 52 |
| WOS 分野 | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CHO |