Reference - Detail
RRC ID | 45510 |
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Author | Hasegawa Y, Kadota Y, Hasegawa C, Kawaminami S. |
Title | Lignosulfonic Acid-Induced Inhibition of Intestinal Glucose Absorption. |
Journal | J Nutr Sci Vitaminol (Tokyo) |
Abstract |
Lignosulfonic acid is a waste lignin produced from the sulfite pulping of softwood. We investigated the effect of lignosulfonic acid on α-glucosidase and found that lignosulfonic acid produced a reversible and non-competitive inhibition of the enzyme activity. Moreover, in human colorectal adenocarcinoma cells, lignosulfonic acid inhibited 2-deoxyglucose uptake, while in vivo studies demonstrated a significant reduction in the blood glycemic response to sucrose or glucose ingestion in rats treated with lignosulfonic acid. Feces of rats fed a diet supplemented with 5% lignosulfonic acid had higher sugar content compared to those of rats fed a control diet. These results suggest that lignosulfonic acid suppresses the rise in blood glucose levels through inhibition of α-glucosidase activity and intestinal glucose absorption. |
Volume | 61(6) |
Pages | 449-54 |
Published | 2015-1-1 |
DOI | 10.3177/jnsv.61.449 |
PMID | 26875485 |
MeSH | 3T3-L1 Cells Animals Blood Glucose / metabolism Caco-2 Cells Carbohydrate Metabolism / drug effects Cell Line, Tumor Colon / drug effects Colon / metabolism Deoxyglucose / metabolism Dietary Supplements Feces / chemistry Glucose / metabolism* Glycoside Hydrolase Inhibitors / pharmacology* Humans Industrial Waste Intestinal Absorption / drug effects* Intestinal Mucosa / metabolism Intestines / drug effects Lignin / pharmacology* Male Mice Plant Extracts / pharmacology* Rats, Wistar Sulfonic Acids / pharmacology* Wood / chemistry alpha-Glucosidases / metabolism* |
IF | 1.424 |
Times Cited | 9 |
WOS Category | NUTRITION & DIETETICS |
Resource | |
Human and Animal Cells | CACO-2(RCB0988) |