論文 - 詳細
| RRC ID | 45700 |
|---|---|
| 著者 | Castelein N, Cai H, Rasulova M, Braeckman BP. |
| タイトル | Lifespan regulation under axenic dietary restriction: a close look at the usual suspects. |
| ジャーナル | Exp Gerontol |
| Abstract |
In Caenorhabditis elegans, there are several ways to impose dietary restriction (DR) all of which extend lifespan to a different degree. Until recently, the molecular mechanisms underlying the DR-mediated lifespan extension were completely unknown but extensive efforts led to the identification of several key players in this process. Culture in sterile axenic medium is a method of DR (ADR), leading to an impressive doubling of lifespan. Earlier, we established that ADR-mediated longevity is independent of Ins/IGF signaling and eat-2. The only gene reported to be indispensable for the ADR lifespan effect is cbp-1 (Zhang et al., 2009) which was confirmed in this study. In an attempt to identify more genes involved in ADR-mediated longevity, we tested several candidate genes known to regulate lifespan extension in other DR regimens. We found that cup-4 is equally important as cbp-1 in ADR-mediated longevity and we identified some genes that may contribute to ADR-induced longevity, but are not required for the full lifespan effect. |
| 巻・号 | 58 |
| ページ | 96-103 |
| 公開日 | 2014-10-1 |
| DOI | 10.1016/j.exger.2014.07.015 |
| PII | S0531-5565(14)00229-0 |
| PMID | 25066271 |
| MeSH | Age Factors Animals Axenic Culture Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Caloric Restriction* Energy Metabolism / genetics Gene Expression Regulation Germ-Free Life Histone Acetyltransferases / genetics Histone Acetyltransferases / metabolism* Longevity* / genetics Transcription Factors / genetics Transcription Factors / metabolism* |
| IF | 3.376 |
| 引用数 | 5 |
| WOS 分野 | GERIATRICS & GERONTOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2984 |